biostudies-literatureUnknown6Cheng RDental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in their early stages. Photoacoustic imaging is an emerging hybrid technology combining the high spatial resolution of ultrasound in deep tissue with the rich optical contrasts. In this study, a dual-contrast photoacoustic tomography is applied to detect the early dental lesions. One contrast, named B-mode, is related to the optical absorption. It is good at providing the sharp image about the morphological and macro-structural features of the teeth. Another contrast, named S-mode, is associated withScientific reports21798https://www.ebi.ac.uk/biostudies/studies/S-EPMC4763185biostudies-literatureNoninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography.PMC4763185Liu XShao JCheng RTao CGe JGao XfalseNoninvasive Assessment of Early Dental Lesion Using a Dual-Contrast Photoacoustic Tomography.Dental hard tissue lesions, including caries, cracked-tooth, etc., are the most prevalent diseases of people worldwide. Dental lesions and correlative diseases greatly decrease the life quality of patients throughout their lifetime. It is still hard to noninvasively detect these dental lesions in their early stages. Photoacoustic imaging is an emerging hybrid technology combining the high spatial resolution of ultrasound in deep tissue with the rich optical contrasts. In this study, a dual-contrast photoacoustic tomography is applied to detect the early dental lesions. One contrast, named B-mode, is related to the optical absorption. It is good at providing the sharp image about the morphological and macro-structural features of the teeth. Another contrast, named S-mode, is associated with2016-01-01T00:00:00Z2016 Feb2025-04-26T01:50:56.657Z2019-03-27T02:09:38ZS-EPMC47631852690239410.1038/srep21798