{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Cong Y"],"pubmed_abstract":["Gene therapies represent a promising therapeutic route for liver cancers, but major challenges remain in the design of safe and efficient gene-targeting delivery systems. For example, cationic polymers show good transfection efficiency as gene carriers, but are hindered by cytotoxicity and non-specific targeting. Here we report a versatile method of one-step conjugation of glycyrrhetinic acid (GA) to reduce cytotoxicity and improve the cultured liver cell -targeting capability of cationic polymers. We have explored a series of cationic polymer derivatives by coupling different ratios of GA to polypropylenimine (PPI) dendrimer. These new gene carriers (GA-PPI dendrimer) were systematically characterized by UV-vis,(1)H NMR titration, electron microscopy, zeta potential, dynamic light-scatter"],"journal":["Scientific reports"],"pagination":["21891"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4763221"],"repository":["biostudies-literature"],"pubmed_title":["One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell."],"pmcid":["PMC4763221"],"pubmed_authors":["Shi B","Lu Y","Chung R","Jin D","Cong Y","Wen S"],"additional_accession":[]},"is_claimable":false,"name":"One-step Conjugation of Glycyrrhetinic Acid to Cationic Polymers for High-performance Gene Delivery to Cultured Liver Cell.","description":"Gene therapies represent a promising therapeutic route for liver cancers, but major challenges remain in the design of safe and efficient gene-targeting delivery systems. For example, cationic polymers show good transfection efficiency as gene carriers, but are hindered by cytotoxicity and non-specific targeting. Here we report a versatile method of one-step conjugation of glycyrrhetinic acid (GA) to reduce cytotoxicity and improve the cultured liver cell -targeting capability of cationic polymers. We have explored a series of cationic polymer derivatives by coupling different ratios of GA to polypropylenimine (PPI) dendrimer. These new gene carriers (GA-PPI dendrimer) were systematically characterized by UV-vis,(1)H NMR titration, electron microscopy, zeta potential, dynamic light-scatter","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2025-04-26T01:52:51.201Z","creation":"2019-03-27T02:09:38Z"},"accession":"S-EPMC4763221","cross_references":{"pubmed":["26902258"],"doi":["10.1038/srep21891"]}}