{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3"],"submitter":["Naesgaard PA"],"pubmed_abstract":["BACKGROUND:Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate. OBJECTIVES:To assess two cut-off levels, 40 and 70?nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome. METHODS:We investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis. RESULTS:Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40?nmol/L and a decrease in cardiac death above a cut-off level of 70?nmol/L [HRs of 0.66 (95% CI, 0.50-0.88), p?=?0.004 and 0.46 (95% CI, 0.22-0.94), p?=?0.034, respectively]. CONCLUSION:Vitamin D cut-off levels of 40 and 70?nmol/L were related to total mortality and cardiac death, respectively."],"journal":["Frontiers in cardiovascular medicine"],"pagination":["4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4767896"],"repository":["biostudies-literature"],"pubmed_title":["Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome."],"pmcid":["PMC4767896"],"pubmed_authors":["Ponitz V","Grundt H","Nilsen ST","Brugger-Andersen T","Staines H","Naesgaard PA","Leon de la Fuente RA","Nilsen DW"],"additional_accession":[]},"is_claimable":false,"name":"Suggested Cut-Off Values for Vitamin D as a Risk Marker for Total and Cardiac Death in Patients with Suspected Acute Coronary Syndrome.","description":"BACKGROUND:Several studies have demonstrated an association between low vitamin D levels and cardiovascular risk. Vitamin D cut-off levels are still under debate. OBJECTIVES:To assess two cut-off levels, 40 and 70?nmol/L, respectively, for vitamin D measured as 25-hydroxyvitamin D in chest pain patients with suspected acute coronary syndrome. METHODS:We investigated 1853 patients from coastal-Norway and inland Northern-Argentina. A similar database was used for pooling of data. Two-year follow-up data including all-cause mortality, cardiac death, and sudden cardiac death in the total patient population were analyzed, applying univariate and multivariable analysis. RESULTS:Two hundred fifty-five patients with known vitamin D concentrations died. In the multivariable analysis, there was a decrease in total mortality above a cut-off level of 40?nmol/L and a decrease in cardiac death above a cut-off level of 70?nmol/L [HRs of 0.66 (95% CI, 0.50-0.88), p?=?0.004 and 0.46 (95% CI, 0.22-0.94), p?=?0.034, respectively]. CONCLUSION:Vitamin D cut-off levels of 40 and 70?nmol/L were related to total mortality and cardiac death, respectively.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2021-02-19T10:39:39Z","creation":"2019-03-27T02:09:56Z"},"accession":"S-EPMC4767896","cross_references":{"pubmed":["26955633"],"doi":["10.3389/fcvm.2016.00004"]}}