biostudies-literatureUnknown11(3)Arya PNACHT NTPases and AP-ATPases belongs to STAND (signal transduction ATPases with numerous domain) P-loop NTPase class, which are known to be involved in defense signaling pathways and apoptosis regulation. The AP-ATPases (also known as NB-ARC) and NACHT NTPases are widely spread throughout all kingdoms of life except in plants, where only AP-ATPases have been extensively studied in the scenario of plant defense response against pathogen invasion and in hypersensitive response (HR). In the present study, we have employed a genome-wide survey (using stringent computational analysis) of 67 diverse organisms viz., archaebacteria, cyanobacteria, fungi, animalia and plantae to revisit the evolutionary history of these two STAND P-loop NTPases. This analysis divulged the presence of NACHT NTPases PloS onee0150634https://www.ebi.ac.uk/biostudies/studies/S-EPMC4773052biostudies-literatureComputational Identification Raises a Riddle for Distribution of Putative NACHT NTPases in the Genome of Early Green Plants.PMC4773052Arya PAcharya VfalseComputational Identification Raises a Riddle for Distribution of Putative NACHT NTPases in the Genome of Early Green Plants.NACHT NTPases and AP-ATPases belongs to STAND (signal transduction ATPases with numerous domain) P-loop NTPase class, which are known to be involved in defense signaling pathways and apoptosis regulation. The AP-ATPases (also known as NB-ARC) and NACHT NTPases are widely spread throughout all kingdoms of life except in plants, where only AP-ATPases have been extensively studied in the scenario of plant defense response against pathogen invasion and in hypersensitive response (HR). In the present study, we have employed a genome-wide survey (using stringent computational analysis) of 67 diverse organisms viz., archaebacteria, cyanobacteria, fungi, animalia and plantae to revisit the evolutionary history of these two STAND P-loop NTPases. This analysis divulged the presence of NACHT NTPases 2016-01-01T00:00:00Z20162026-04-07T16:48:55.92Z2019-03-26T22:57:32ZS-EPMC47730522693039610.1371/journal.pone.0150634