{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Dai Y"],"pubmed_abstract":["Oxidized low-density lipoprotein (ox-LDL) is, at least in part, responsible for angiogenesis in atherosclerotic regions. This effect of ox-LDL has been shown to be mediated through a specific receptor LOX-1. Here we describe the effect of miR-590-5p on ox-LDL-mediated angiogenesis in in vitro and in vivo settings. Human umbilical vein endothelial cells (HUVECs) were transfected with miR-590-5p mimic or inhibitor followed by treatment with ox-LDL. In other experiments, Marigel plugs were inserted in the mice subcutaneous space. Both in vitro and in vivo studies showed that miR-590-5p mimic (100 nM) inhibited the ox-LDL-mediated angiogenesis (capillary tube formation, cell proliferation and migration as well as pro-angiogenic signals- ROS, MAPKs, pro-inflammatory cytokines and adhesion-relat"],"journal":["Scientific reports"],"pagination":["22607"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4773867"],"repository":["biostudies-literature"],"pubmed_title":["MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1."],"pmcid":["PMC4773867"],"pubmed_authors":["Mehta JL","Li J","Zhang Z","Cao Y","Dai Y"],"additional_accession":[]},"is_claimable":false,"name":"MiR-590-5p Inhibits Oxidized- LDL Induced Angiogenesis by Targeting LOX-1.","description":"Oxidized low-density lipoprotein (ox-LDL) is, at least in part, responsible for angiogenesis in atherosclerotic regions. This effect of ox-LDL has been shown to be mediated through a specific receptor LOX-1. Here we describe the effect of miR-590-5p on ox-LDL-mediated angiogenesis in in vitro and in vivo settings. Human umbilical vein endothelial cells (HUVECs) were transfected with miR-590-5p mimic or inhibitor followed by treatment with ox-LDL. In other experiments, Marigel plugs were inserted in the mice subcutaneous space. Both in vitro and in vivo studies showed that miR-590-5p mimic (100 nM) inhibited the ox-LDL-mediated angiogenesis (capillary tube formation, cell proliferation and migration as well as pro-angiogenic signals- ROS, MAPKs, pro-inflammatory cytokines and adhesion-relat","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-04-18T22:03:54.462Z","creation":"2019-03-27T02:10:17Z"},"accession":"S-EPMC4773867","cross_references":{"pubmed":["26932825"],"doi":["10.1038/srep22607"]}}