{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Moog NK"],"funding":["NICHD NIH HHS","US PHS","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["831-839"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4777678"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(10)"],"pubmed_abstract":["<h4>Background</h4>The effects of exposure to childhood trauma (CT) may be transmitted across generations; however, the time period(s) and mechanism(s) have yet to be clarified. We address the hypothesis that intergenerational transmission may begin during intrauterine life via the effect of maternal CT exposure on placental-fetal stress physiology, specifically placental corticotropin-releasing hormone (pCRH).<h4>Methods</h4>The study was conducted in a sociodemographically diverse cohort of 295 pregnant women. CT exposure was assessed using the Childhood Trauma Questionnaire. Placental CRH concentrations were quantified in maternal blood collected serially over the course of gestation. Linear mixed effects and Bayesian piece-wise linear models were employed to test hypothesized relationships.<h4>Results</h4>Maternal CT exposure (CT+) was significantly associated with pCRH production. Compared with nonexposed women, CT+ was associated with an almost 25% increase in pCRH toward the end of gestation, and the pCRH trajectory of CT+ women exhibited an approximately twofold steeper increase after the pCRH inflection point at 19 weeks gestation.<h4>Conclusions</h4>To the best of our knowledge, this finding represents the first report linking maternal CT exposure with placental-fetal stress physiology, thus identifying a potential novel biological pathway of intergenerational transmission that may operate as early as during intrauterine life."],"journal":["Biological psychiatry"],"pubmed_title":["Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology."],"pmcid":["PMC4777678"],"funding_grant_id":["PO1 HD-047609","RO1 MH-105538","R01 HD041696","R01 HD060628","R01 NS041298","R01 HD-041696","R29 HD-33506","R01 MH105538","RO1 HD-060628","R01 NS-41298","P01 HD047609","R29 HD033506"],"pubmed_authors":["Buss C","Hobel CJ","Entringer S","Moog NK","Wadhwa PD","Gillen DL","Shahbaba B"],"additional_accession":[]},"is_claimable":false,"name":"Maternal Exposure to Childhood Trauma Is Associated During Pregnancy With Placental-Fetal Stress Physiology.","description":"<h4>Background</h4>The effects of exposure to childhood trauma (CT) may be transmitted across generations; however, the time period(s) and mechanism(s) have yet to be clarified. We address the hypothesis that intergenerational transmission may begin during intrauterine life via the effect of maternal CT exposure on placental-fetal stress physiology, specifically placental corticotropin-releasing hormone (pCRH).<h4>Methods</h4>The study was conducted in a sociodemographically diverse cohort of 295 pregnant women. CT exposure was assessed using the Childhood Trauma Questionnaire. Placental CRH concentrations were quantified in maternal blood collected serially over the course of gestation. Linear mixed effects and Bayesian piece-wise linear models were employed to test hypothesized relationships.<h4>Results</h4>Maternal CT exposure (CT+) was significantly associated with pCRH production. Compared with nonexposed women, CT+ was associated with an almost 25% increase in pCRH toward the end of gestation, and the pCRH trajectory of CT+ women exhibited an approximately twofold steeper increase after the pCRH inflection point at 19 weeks gestation.<h4>Conclusions</h4>To the best of our knowledge, this finding represents the first report linking maternal CT exposure with placental-fetal stress physiology, thus identifying a potential novel biological pathway of intergenerational transmission that may operate as early as during intrauterine life.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2024-11-05T20:09:58.442Z","creation":"2019-03-27T02:10:27Z"},"accession":"S-EPMC4777678","cross_references":{"pubmed":["26444076"],"doi":["10.1016/j.biopsych.2015.08.032"]}}