{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wong LC"],"funding":["NIMH NIH HHS"],"pagination":["593-604"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4783202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(5)"],"pubmed_abstract":["Aggression is a prevalent behavior in the animal kingdom that is used to settle competition for limited resources. Given the high risk associated with fighting, the central nervous system has evolved an active mechanism to modulate its expression. Lesioning the lateral septum (LS) is known to cause \"septal rage,\" a phenotype characterized by a dramatic increase in the frequency of attacks. To understand the circuit mechanism of LS-mediated modulation of aggression, we examined the influence of LS input on the cells in and around the ventrolateral part of the ventromedial hypothalamus (VMHvl)-a region required for male mouse aggression. We found that the inputs from the LS inhibited the attack-excited cells but surprisingly increased the overall activity of attack-inhibited cells. Furthermo"],"journal":["Current biology : CB"],"pubmed_title":["Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection."],"pmcid":["PMC4783202"],"funding_grant_id":["R01 MH101377","1R01MH101377"],"pubmed_authors":["Wong LC","Froemke RC","Lin D","Yumita T","Yamaguchi T","Chang BC","Chen G","Feng JE","D'Amour JA","Bernstein H","You X","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Effective Modulation of Male Aggression through Lateral Septum to Medial Hypothalamus Projection.","description":"Aggression is a prevalent behavior in the animal kingdom that is used to settle competition for limited resources. Given the high risk associated with fighting, the central nervous system has evolved an active mechanism to modulate its expression. Lesioning the lateral septum (LS) is known to cause \"septal rage,\" a phenotype characterized by a dramatic increase in the frequency of attacks. To understand the circuit mechanism of LS-mediated modulation of aggression, we examined the influence of LS input on the cells in and around the ventrolateral part of the ventromedial hypothalamus (VMHvl)-a region required for male mouse aggression. We found that the inputs from the LS inhibited the attack-excited cells but surprisingly increased the overall activity of attack-inhibited cells. Furthermo","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-05-29T22:25:55.233Z","creation":"2019-03-27T02:10:41Z"},"accession":"S-EPMC4783202","cross_references":{"pubmed":["26877081"],"doi":["10.1016/j.cub.2015.12.065"]}}