{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["O'Brien TF"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["597-609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4785102"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Invariant natural killer T (iNKT) cells produce cytokines interleukin-4 (IL-4) and IL-13 during type-2 inflammatory responses. However, the nature in which iNKT cells acquire type-2 cytokine competency and the precise contribution of iNKT cell-derived IL-4 and IL-13 in vivo remains unclear. Using IL-13-reporter mice to fate-map cytokine-expressing cells in vivo, this study reveals that thymic iNKT cells express IL-13 early during development, and this IL-13-expressing intermediate gives rise to mature iNKT1, iNKT2, and iNKT17 subsets. IL-4 and IL-13 reporter mice also reveal that effector iNKT2 cells produce IL-4 but little IL-13 in settings of type-2 inflammation. The preferential production of IL-4 over IL-13 in iNKT2 cells results in part from their reduced GATA-3 expression. In summary, this work helps integrate current models of iNKT cell development, and further establishes non-coordinate production of IL-4 and IL-13 as the predominant pattern of type-2 cytokine expression among innate cells in vivo."],"journal":["Mucosal immunology"],"pubmed_title":["Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation."],"pmcid":["PMC4785102"],"funding_grant_id":["T32 GM007184","R01 AI119004","T32 AI052077"],"pubmed_authors":["Abraham S","O'Brien TF","Bao K","Dell'Aringa M","Reinhardt RL","Ang WX"],"additional_accession":[]},"is_claimable":false,"name":"Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation.","description":"Invariant natural killer T (iNKT) cells produce cytokines interleukin-4 (IL-4) and IL-13 during type-2 inflammatory responses. However, the nature in which iNKT cells acquire type-2 cytokine competency and the precise contribution of iNKT cell-derived IL-4 and IL-13 in vivo remains unclear. Using IL-13-reporter mice to fate-map cytokine-expressing cells in vivo, this study reveals that thymic iNKT cells express IL-13 early during development, and this IL-13-expressing intermediate gives rise to mature iNKT1, iNKT2, and iNKT17 subsets. IL-4 and IL-13 reporter mice also reveal that effector iNKT2 cells produce IL-4 but little IL-13 in settings of type-2 inflammation. The preferential production of IL-4 over IL-13 in iNKT2 cells results in part from their reduced GATA-3 expression. In summary, this work helps integrate current models of iNKT cell development, and further establishes non-coordinate production of IL-4 and IL-13 as the predominant pattern of type-2 cytokine expression among innate cells in vivo.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2026-05-29T20:39:22.875Z","creation":"2019-03-27T02:10:46Z"},"accession":"S-EPMC4785102","cross_references":{"pubmed":["26349658"],"doi":["10.1038/mi.2015.78"]}}