biostudies-literatureZhao FNICHD NIH HHS23037https://www.ebi.ac.uk/biostudies/studies/S-EPMC4786858biostudies-literatureUnknown6Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving initiation, elongation and differentiation. Genetic basis solely for distal reproductive tract development is largely unknown. Lhfpl2 (lipoma HMGIC fusion partner-like 2) encodes a tetra-transmembrane protein with unknown functions. It is expressed in follicle cells of ovary and epithelial cells of reproductive tracts. A spontaneous point mutation of Lhfpl2 (LHFPL2(G102E)) leads to infertility in 100% female mice, which have normal ovarian development, ovulation, uterine development, and uterine response to exogenous estrogen stimulation, but abnormal upper longitudinal vaginal septum and lower vaginal agenesis. IScientific reportsNovel function of LHFPL2 in female and male distal reproductive tract development.PMC4786858R01 HD065939R15HD066301R01HD065939R15 HD066301Dudley EAZhao FLi RYe XZhou JfalseNovel function of LHFPL2 in female and male distal reproductive tract development.Congenital reproductive tract anomalies could impair fertility. Female and male reproductive tracts are developed from Müllerian ducts and Wolffian ducts, respectively, involving initiation, elongation and differentiation. Genetic basis solely for distal reproductive tract development is largely unknown. Lhfpl2 (lipoma HMGIC fusion partner-like 2) encodes a tetra-transmembrane protein with unknown functions. It is expressed in follicle cells of ovary and epithelial cells of reproductive tracts. A spontaneous point mutation of Lhfpl2 (LHFPL2(G102E)) leads to infertility in 100% female mice, which have normal ovarian development, ovulation, uterine development, and uterine response to exogenous estrogen stimulation, but abnormal upper longitudinal vaginal septum and lower vaginal agenesis. I2016-01-01T00:00:00Z2016 Mar2025-04-18T22:04:19.653Z2019-03-27T02:10:52ZS-EPMC47868582696490010.1038/srep23037