biostudies-literatureGong YNational Natural Science Foundation of China Youth ProjectsBeijing natural science foundationNational Natural Science Foundation of ChinaScientific Research Base Construction-Scientific and Technological Innovation Platform Metabolic Disorders Related Cardiovascular Diseases Research Platform Construction584-93https://www.ebi.ac.uk/biostudies/studies/S-EPMC4788697biostudies-literatureUnknown64(2)Diabetes mellitus is a chronic metabolic disorder with a high morbidity and mortality, but its pathogenesis is not fully understood. An increasing amount of evidence indicates that an immune mechanism plays an important role in the pathogenesis of diabetes. We demonstrated previously that the long-term presence of autoantibodies against the second extracellular loop of the β1-adrenoceptor (β1-AA) could change the ratio of peripheral CD4+T/CD8+T in rats, which was accompanied by lymphocytes infiltration in the rat heart, liver, and kidneys. To investigate whether β1-AA is involved in the pathogenesis of diabetes, BALB/c or nude mice were passively immunized with monoclonal antibodies against β1-AR (β1-AR mAb). Compared with vehicle control mice, β1-AA-positive BALB/c mice exhibited significImmunologic researchAutoantibodies against β1-adrenoceptor induce blood glucose enhancement and insulin insufficient via T lymphocytes.PMC478869781300694PXM2015_014226_0000622014CB5607007151001Liu HLi XDu YZhang SGong YWu YXiong HfalseAutoantibodies against β1-adrenoceptor induce blood glucose enhancement and insulin insufficient via T lymphocytes.Diabetes mellitus is a chronic metabolic disorder with a high morbidity and mortality, but its pathogenesis is not fully understood. An increasing amount of evidence indicates that an immune mechanism plays an important role in the pathogenesis of diabetes. We demonstrated previously that the long-term presence of autoantibodies against the second extracellular loop of the β1-adrenoceptor (β1-AA) could change the ratio of peripheral CD4+T/CD8+T in rats, which was accompanied by lymphocytes infiltration in the rat heart, liver, and kidneys. To investigate whether β1-AA is involved in the pathogenesis of diabetes, BALB/c or nude mice were passively immunized with monoclonal antibodies against β1-AR (β1-AR mAb). Compared with vehicle control mice, β1-AA-positive BALB/c mice exhibited signific2016-01-01T00:00:00Z2016 Apr2025-04-18T22:05:16.071Z2019-03-27T02:10:57ZS-EPMC47886972663935410.1007/s12026-015-8757-7