biostudies-literatureSleeper LANHLBI NIH HHS173-80.e1-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4790092biostudies-literatureUnknown170<h4>Objectives</h4>To measure the health-related quality of life (HRQOL) and functional status of children with cardiomyopathy and to determine whether they are correlated with sociodemographics, cardiac status, and clinical outcomes.<h4>Study design</h4>Parents of children in the Pediatric Cardiomyopathy Registry completed the Child Health Questionnaire (CHQ; age ≥ 5 years) and Functional Status II (Revised) (age ≤ 18 years) instruments. Linear and Cox regressions were used to examine hypothesized associations with HRQOL.<h4>Results</h4>The 355 children evaluated at ≥ 5 years (median 8.6 years) had lower functioning (CHQ Physical and Psychosocial Summary Scores 41.7 ± 14.4 and 47.8 ± 10.7) than that of healthy historical controls. The most extreme CHQ domain score, Parental Impact-EmotionThe Journal of pediatricsHealth-Related Quality of Life and Functional Status Are Associated with Cardiac Status and Clinical Outcome in Children with Cardiomyopathy.PMC4790092R01 HL053392R01 HL HL53392Everitt MAddonizio LEpstein SRusconi PKorsin RKaufman BMcDonald MNoonan KCzachor JRees MAKantor PHill-Edgar ABenson LPophali NLowe AGurell MJefferies JLO'Brien RGrenier MASteeg CShaddy RGiantris ALewis KBuzzard CMuto ECuniberti LShaikh SCanter CPediatric Cardiomyopathy Registry InvestigatorsFountain DCarron HMiller TLMessere JPahl ELu MRauch EGidding SGilroy LCafferata LWilk DDauphin DLemler MSChrisant MCianfrini CTighe FLemler MClunie SWilkinson JDKeesler MColan SSleeper LALurie PFixler DTamer DColan SDWolfe GNewman AMcKee TTruesdell SSullivan WAlvarez JAOsganian SAlvarez JHsu DWebber SOrfaly RArsenault PExil VSleeper LMeloche MTowbin JRossetti ROrav EJSchiavoni LStrauss ARossano JLipshultz SEMcCoy KRossetti LCox GRodgers STowbin JAfalseHealth-Related Quality of Life and Functional Status Are Associated with Cardiac Status and Clinical Outcome in Children with Cardiomyopathy.<h4>Objectives</h4>To measure the health-related quality of life (HRQOL) and functional status of children with cardiomyopathy and to determine whether they are correlated with sociodemographics, cardiac status, and clinical outcomes.<h4>Study design</h4>Parents of children in the Pediatric Cardiomyopathy Registry completed the Child Health Questionnaire (CHQ; age ≥ 5 years) and Functional Status II (Revised) (age ≤ 18 years) instruments. Linear and Cox regressions were used to examine hypothesized associations with HRQOL.<h4>Results</h4>The 355 children evaluated at ≥ 5 years (median 8.6 years) had lower functioning (CHQ Physical and Psychosocial Summary Scores 41.7 ± 14.4 and 47.8 ± 10.7) than that of healthy historical controls. The most extreme CHQ domain score, Parental Impact-Emotion2016-01-01T00:00:00Z2016 Mar2025-04-20T02:40:28.749Z2019-03-27T02:11:02ZS-EPMC47900922672545910.1016/j.jpeds.2015.10.004