{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Contopoulos-Ioannidis DG"],"funding":["NICHD NIH HHS","Eunice Kennedy Shriver National Institute of Child Health &amp; Human Development","National Institutes of Health"],"pagination":["1098-105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4790625"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71(4)"],"pubmed_abstract":["<h4>Objectives</h4>Antibiotics increase weight in farm animals and may cause weight gain in humans. We used electronic health records from a large primary care organization to determine the effect of antibiotics on weight and BMI in healthy adolescents with acne.<h4>Methods</h4>We performed a retrospective cohort study of adolescents with acne prescribed ≥4 weeks of oral antibiotics with weight measurements within 18 months pre-antibiotics and 12 months post-antibiotics. We compared within-individual changes in weight-for-age Z-scores (WAZs) and BMI-for-age Z-scores (BMIZs). We used: (i) paired t-tests to analyse changes between the last pre-antibiotics versus the first post-antibiotic measurements; (ii) piecewise-constant-mixed models to capture changes between mean measurements pre- vers"],"journal":["The Journal of antimicrobial chemotherapy"],"pubmed_title":["Effect of long-term antibiotic use on weight in adolescents with acne."],"pmcid":["PMC4790625"],"funding_grant_id":["R01 HD063142","R03HD072400"],"pubmed_authors":["Contopoulos-Ioannidis DG","Parsonnet J","Luft HS","Olson C","Hastie T","Wang W","Ma T","Ley C","Shi X"],"additional_accession":[]},"is_claimable":false,"name":"Effect of long-term antibiotic use on weight in adolescents with acne.","description":"<h4>Objectives</h4>Antibiotics increase weight in farm animals and may cause weight gain in humans. We used electronic health records from a large primary care organization to determine the effect of antibiotics on weight and BMI in healthy adolescents with acne.<h4>Methods</h4>We performed a retrospective cohort study of adolescents with acne prescribed ≥4 weeks of oral antibiotics with weight measurements within 18 months pre-antibiotics and 12 months post-antibiotics. We compared within-individual changes in weight-for-age Z-scores (WAZs) and BMI-for-age Z-scores (BMIZs). We used: (i) paired t-tests to analyse changes between the last pre-antibiotics versus the first post-antibiotic measurements; (ii) piecewise-constant-mixed models to capture changes between mean measurements pre- vers","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-26T09:16:57.454Z","creation":"2019-03-27T02:11:02Z"},"accession":"S-EPMC4790625","cross_references":{"pubmed":["26782773"],"doi":["10.1093/jac/dkv455"]}}