biostudies-literatureYadlapati RNIDDK NIH HHSAHRQ HHS535-542.e2https://www.ebi.ac.uk/biostudies/studies/S-EPMC4799733biostudies-literatureUnknown14(4)<h4>Background & aims</h4>It has been a challenge to confirm the association between laryngeal symptoms and physiological reflux disease. We examined the ability of oropharyngeal pH tests (with the Restech Dx-pH system) and salivary pepsin tests (with Peptest) to discriminate between asymptomatic volunteers (controls) and subjects with a combination of laryngeal and reflux symptoms (laryngeal ± reflux).<h4>Methods</h4>We performed a physician-blinded prospective cohort study of 59 subjects at a single academic institution. Adult volunteers were recruited and separated into 3 groups on the basis of GerdQ and Reflux Symptom Index scores: controls (n = 20), laryngeal symptoms (n = 20), or laryngeal + reflux symptoms (n = 19). Subjects underwent laryngoscopy and oropharyngeal pH tests and submClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological AssociationAbilities of Oropharyngeal pH Tests and Salivary Pepsin Analysis to Discriminate Between Asymptomatic Volunteers and Subjects With Symptoms of Laryngeal Irritation.PMC4799733T32DK101363-02K12 HS023011T32 DK101363Lidder AKEllenbogen MAdkins CTan BKJaiyeola DMYadlapati RSmith SSPrice CPPandolfino JEShabeeb NBove MAgrawal NGawron AJfalseAbilities of Oropharyngeal pH Tests and Salivary Pepsin Analysis to Discriminate Between Asymptomatic Volunteers and Subjects With Symptoms of Laryngeal Irritation.<h4>Background & aims</h4>It has been a challenge to confirm the association between laryngeal symptoms and physiological reflux disease. We examined the ability of oropharyngeal pH tests (with the Restech Dx-pH system) and salivary pepsin tests (with Peptest) to discriminate between asymptomatic volunteers (controls) and subjects with a combination of laryngeal and reflux symptoms (laryngeal ± reflux).<h4>Methods</h4>We performed a physician-blinded prospective cohort study of 59 subjects at a single academic institution. Adult volunteers were recruited and separated into 3 groups on the basis of GerdQ and Reflux Symptom Index scores: controls (n = 20), laryngeal symptoms (n = 20), or laryngeal + reflux symptoms (n = 19). Subjects underwent laryngoscopy and oropharyngeal pH tests and subm2016-01-01T00:00:00Z2016 Apr2025-04-22T12:04:28.548Z2019-03-27T02:11:27ZS-EPMC47997332668989910.1016/j.cgh.2015.11.017