{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Binepal G"],"funding":["Canadian Institutes of Health Research","Gouvernement du Canada | Canadian Institutes of Health Research"],"pagination":["1087-100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4800877"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["198(7)"],"pubmed_abstract":["<h4>Unlabelled</h4>Potassium (K(+)) is the most abundant cation in the fluids of dental biofilm. The biochemical and biophysical functions of K(+) and a variety of K(+) transport systems have been studied for most pathogenic bacteria but not for oral pathogens. In this study, we establish the modes of K(+) acquisition in Streptococcus mutans and the importance of K(+) homeostasis for its virulence attributes. The S. mutans genome harbors four putative K(+) transport systems that included two Trk-like transporters (designated Trk1 and Trk2), one glutamate/K(+) cotransporter (GlnQHMP), and a channel-like K(+) transport system (Kch). Mutants lacking Trk2 had significantly impaired growth, acidogenicity, aciduricity, and biofilm formation. [K(+)] less than 5 mM eliminated biofilm formation in "],"journal":["Journal of bacteriology"],"pubmed_title":["Trk2 Potassium Transport System in Streptococcus mutans and Its Role in Potassium Homeostasis, Biofilm Formation, and Stress Tolerance."],"pmcid":["PMC4800877"],"funding_grant_id":["MT-15431"],"pubmed_authors":["Cordova M","Cvitkovitch DG","Senadheera DB","Binepal G","Brady LJ","Crowley P","Gill K"],"additional_accession":[]},"is_claimable":false,"name":"Trk2 Potassium Transport System in Streptococcus mutans and Its Role in Potassium Homeostasis, Biofilm Formation, and Stress Tolerance.","description":"<h4>Unlabelled</h4>Potassium (K(+)) is the most abundant cation in the fluids of dental biofilm. The biochemical and biophysical functions of K(+) and a variety of K(+) transport systems have been studied for most pathogenic bacteria but not for oral pathogens. In this study, we establish the modes of K(+) acquisition in Streptococcus mutans and the importance of K(+) homeostasis for its virulence attributes. The S. mutans genome harbors four putative K(+) transport systems that included two Trk-like transporters (designated Trk1 and Trk2), one glutamate/K(+) cotransporter (GlnQHMP), and a channel-like K(+) transport system (Kch). Mutants lacking Trk2 had significantly impaired growth, acidogenicity, aciduricity, and biofilm formation. [K(+)] less than 5 mM eliminated biofilm formation in ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Jan","modification":"2025-04-26T01:49:10.541Z","creation":"2019-03-27T03:09:55Z"},"accession":"S-EPMC4800877","cross_references":{"pubmed":["26811321"],"doi":["10.1128/JB.00813-15","10.1128/jb.00813-15"]}}