{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Monai H"],"pubmed_abstract":["Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP3R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca(2+) surges are absent. Togethe"],"journal":["Nature communications"],"pagination":["11100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4804173"],"repository":["biostudies-literature"],"pubmed_title":["Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain."],"pmcid":["PMC4804173"],"pubmed_authors":["Hirai H","Hirase H","Konno A","Iwai Y","Nakai J","Monai H","Oe Y","Itohara S","Ohkura M","Tanaka M","Mikoshiba K"],"additional_accession":[]},"is_claimable":false,"name":"Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain.","description":"Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various neurological conditions and enhance memory and cognition in humans. tDCS has gained traction for its potential therapeutic value; however, little is known about its mechanism of action. Using a transgenic mouse expressing G-CaMP7 in astrocytes and a subpopulation of excitatory neurons, we find that tDCS induces large-amplitude astrocytic Ca(2+) surges across the entire cortex with no obvious changes in the local field potential. Moreover, sensory evoked cortical responses are enhanced after tDCS. These enhancements are dependent on the alpha-1 adrenergic receptor and are not observed in IP3R2 (inositol trisphosphate receptor type 2) knockout mice, in which astrocytic Ca(2+) surges are absent. Togethe","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-04-04T11:41:33.092Z","creation":"2019-03-27T03:10:07Z"},"accession":"S-EPMC4804173","cross_references":{"pubmed":["27000523"],"doi":["10.1038/ncomms11100"]}}