{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jones DT"],"funding":["NIA NIH HHS"],"pagination":["547-62"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4805086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["139(Pt 2)"],"pubmed_abstract":["Complex biological systems are organized across various spatiotemporal scales with particular scientific disciplines dedicated to the study of each scale (e.g. genetics, molecular biology and cognitive neuroscience). When considering disease pathophysiology, one must contemplate the scale at which the disease process is being observed and how these processes impact other levels of organization. Historically Alzheimer's disease has been viewed as a disease of abnormally aggregated proteins by pathologists and molecular biologists and a disease of clinical symptoms by neurologists and psychologists. Bridging the divide between these scales has been elusive, but the study of brain networks appears to be a pivotal inroad to accomplish this task. In this study, we were guided by an emerging sys"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Cascading network failure across the Alzheimer's disease spectrum."],"pmcid":["PMC4805086"],"funding_grant_id":["R01 AG011378","U01 AG024904","AG04185"],"pubmed_authors":["Graff-Radford J","Weiner MW","Gunter JL","Jack CR","Knopman DS","Jones DT","Boeve BF","Vemuri P","Petersen RC","Alzheimer’s Disease Neuroimaging Initiative"],"additional_accession":[]},"is_claimable":false,"name":"Cascading network failure across the Alzheimer's disease spectrum.","description":"Complex biological systems are organized across various spatiotemporal scales with particular scientific disciplines dedicated to the study of each scale (e.g. genetics, molecular biology and cognitive neuroscience). When considering disease pathophysiology, one must contemplate the scale at which the disease process is being observed and how these processes impact other levels of organization. Historically Alzheimer's disease has been viewed as a disease of abnormally aggregated proteins by pathologists and molecular biologists and a disease of clinical symptoms by neurologists and psychologists. Bridging the divide between these scales has been elusive, but the study of brain networks appears to be a pivotal inroad to accomplish this task. In this study, we were guided by an emerging sys","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Feb","modification":"2026-05-05T16:47:49.787Z","creation":"2019-03-26T23:05:29Z"},"accession":"S-EPMC4805086","cross_references":{"pubmed":["26586695"],"doi":["10.1093/brain/awv338"]}}