{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lavezzo MM"],"funding":["Fundação de Amparo à Pesquisa do Estado de São Paulo (BR)"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4806431"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele. The absence of ocular trauma or previous intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential diagnosis. The disease has an acute onset of bilateral blurred vision with hyperemia preceded by flu-like symptoms. The acute uveitic stage is characterized by a diffuse choroiditis with serous retinal detachment and optic disc hyperemia and edema. Fluorescein angiography in this phase demonstrates multiple early hyperfluorescent points. After the acute uveitic stag"],"journal":["Orphanet journal of rare diseases"],"pubmed_title":["Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes."],"pmcid":["PMC4806431"],"funding_grant_id":["#2013/07462-0","#2011/19194-4","#2014/01222-0","#2011/50936-7"],"pubmed_authors":["Lavezzo MM","Abdallah SF","Hirata CE","Sakata VM","Yamamoto JH","Rodriguez EE","Morita C","da Silva FT"],"additional_accession":[]},"is_claimable":false,"name":"Vogt-Koyanagi-Harada disease: review of a rare autoimmune disease targeting antigens of melanocytes.","description":"Vogt-Koyanagi-Harada disease (VKHD) is a rare granulomatous inflammatory disease that affects pigmented structures, such as eye, inner ear, meninges, skin and hair. This disease is mainly a Th1 lymphocyte mediated aggression to melanocytes after a viral trigger in the presence of HLA-DRB1*0405 allele. The absence of ocular trauma or previous intraocular surgery sets VKHD appart from sympathetic ophthalmia, its main differential diagnosis. The disease has an acute onset of bilateral blurred vision with hyperemia preceded by flu-like symptoms. The acute uveitic stage is characterized by a diffuse choroiditis with serous retinal detachment and optic disc hyperemia and edema. Fluorescein angiography in this phase demonstrates multiple early hyperfluorescent points. After the acute uveitic stag","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-04-04T08:50:14.011Z","creation":"2019-06-06T15:36:17Z"},"accession":"S-EPMC4806431","cross_references":{"pubmed":["27008848"],"doi":["10.1186/s13023-016-0412-4"]}}