biostudies-literatureUnknown11(3)Tosello F<h4>Introduction</h4>Current evidence suggests that aortic blood pressure has a superior prognostic value with respect to brachial pressure for cardiovascular events, but direct measurement is not feasible in daily clinical practice.<h4>Aim</h4>The aim of the present study is the clinical validation of a multiscale mathematical model for non-invasive appraisal of central blood pressure from subject-specific characteristics.<h4>Methods</h4>A total of 51 young male were selected for the present study. Aortic systolic and diastolic pressure were estimated with a mathematical model and were compared to the most-used non-invasive validated technique (SphygmoCor device, AtCor Medical, Australia). SphygmoCor was calibrated through diastolic and systolic brachial pressure obtained with a sphygmomaPloS onee0151523https://www.ebi.ac.uk/biostudies/studies/S-EPMC4806836biostudies-literatureCentral Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model.PMC4806836Veglio FMilan AGuala ALeone DBruno GRidolfi LTosello FCamporeale CfalseCentral Pressure Appraisal: Clinical Validation of a Subject-Specific Mathematical Model.<h4>Introduction</h4>Current evidence suggests that aortic blood pressure has a superior prognostic value with respect to brachial pressure for cardiovascular events, but direct measurement is not feasible in daily clinical practice.<h4>Aim</h4>The aim of the present study is the clinical validation of a multiscale mathematical model for non-invasive appraisal of central blood pressure from subject-specific characteristics.<h4>Methods</h4>A total of 51 young male were selected for the present study. Aortic systolic and diastolic pressure were estimated with a mathematical model and were compared to the most-used non-invasive validated technique (SphygmoCor device, AtCor Medical, Australia). SphygmoCor was calibrated through diastolic and systolic brachial pressure obtained with a sphygmoma2016-01-01T00:00:00Z20162025-04-04T20:13:00.506Z2019-03-26T22:53:40ZS-EPMC48068362701056210.1371/journal.pone.0151523