biostudies-literatureLafond KEMedical Research CouncilNCIRD CDC HHSe1001977https://www.ebi.ac.uk/biostudies/studies/S-EPMC4807087biostudies-literatureUnknown13(3)<h4>Background</h4>The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide.<h4>Methods and findings</h4>We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group (<6 mo, <1 y, <2 y, <5 y, 5-17 y, and <1PLoS medicineGlobal Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982-2012: A Systematic Analysis.PMC4807087U01 IP001048MC_UP_A900_1116MC_U190088478MC_UP_A900_1124Whaley MMmbaga VEder VPeng ZNkwembe EBerkley JAJasseh MKile JAmpofo WPhonekeo DSuizan ZSturm-Ramirez KBresee JHowie SRBaggett HCTheo ALafond KEEmukule GOAzziz-Baumgartner EBrooks WArmero JRasooly MHHeraud JMGargiullo PRahman MTempia SVenter MGlew PFeng LAdedeji AGlobal Respiratory Hospitalizations—Influenza Proportion Positive (GRIPP) Working GroupLucero MKasymbekova Kde Saude MChittaganpitch MDalhatu IOpe MLal RBvon Horoch MMir Islam Saeed KOlsen SJSampurno ODNair HNguyen THJiang HRazanajatovo NHClara AWSetiawaty VMei SRai SKKitsutani PYu HValente FBurmaa ANjuguna HCojocaru RJima DMwakapeje ESar BCohen ALMott JGuzman GAranda-Romo SCorwin AChadha MBroor SAdje KHNoyola DERoca ASriwanthana BBarakat ANyatanyi TNurmatov ZOlveda RCardoso YWiddowson MANzussouo NTCampbell HTokarz RDemissie GSaha SMamun AAAdjabeng MMonze MKhandaker GRukelibuga JSimoes EABooy RCabello MAMena RCohen CMoen ACoulibaly DNymadawa PfalseGlobal Role and Burden of Influenza in Pediatric Respiratory Hospitalizations, 1982-2012: A Systematic Analysis.<h4>Background</h4>The global burden of pediatric severe respiratory illness is substantial, and influenza viruses contribute to this burden. Systematic surveillance and testing for influenza among hospitalized children has expanded globally over the past decade. However, only a fraction of the data has been used to estimate influenza burden. In this analysis, we use surveillance data to provide an estimate of influenza-associated hospitalizations among children worldwide.<h4>Methods and findings</h4>We aggregated data from a systematic review (n = 108) and surveillance platforms (n = 37) to calculate a pooled estimate of the proportion of samples collected from children hospitalized with respiratory illnesses and positive for influenza by age group (<6 mo, <1 y, <2 y, <5 y, 5-17 y, and <12016-01-01T00:00:00Z2016 Mar2025-04-04T20:13:10.035Z2019-03-26T22:44:39ZS-EPMC48070872701122910.1371/journal.pmed.1001977