biostudies-literatureUnknown39(1)Koppe TThe clinical utility of serum ferritin as a biomarker of disease severity and prognosis in Gaucher disease (GD) is still debated. Here, we aimed to evaluate ferritin and its relation to clinicolaboratory parameters of GD patients seen at the Reference Center for Gaucher Disease of Rio Grande do Sul, Brazil, so as to gather evidence on the utility of ferritin as a biomarker of this condition. A retrospective chart review was performed collecting pre-and posttreatment data from GD patients. Eighteen patients with ferritin levels available before and after treatment were included in the study. Nine of these participants were males, and seventeen had type I GD. All patients were given either enzyme replacement (n = 16) or substrate reduction therapy (n = 2), and ferritin was found to decrease Genetics and molecular biology30-4https://www.ebi.ac.uk/biostudies/studies/S-EPMC4807389biostudies-literatureThe prognostic value of the serum ferritin in a southern Brazilian cohort of patients with Gaucher disease.PMC4807389Siebert MTirelli KMSchwartz IVDoneda DDaudt LCamargo MVairo FPaskulin LKoppe TfalseThe prognostic value of the serum ferritin in a southern Brazilian cohort of patients with Gaucher disease.The clinical utility of serum ferritin as a biomarker of disease severity and prognosis in Gaucher disease (GD) is still debated. Here, we aimed to evaluate ferritin and its relation to clinicolaboratory parameters of GD patients seen at the Reference Center for Gaucher Disease of Rio Grande do Sul, Brazil, so as to gather evidence on the utility of ferritin as a biomarker of this condition. A retrospective chart review was performed collecting pre-and posttreatment data from GD patients. Eighteen patients with ferritin levels available before and after treatment were included in the study. Nine of these participants were males, and seventeen had type I GD. All patients were given either enzyme replacement (n = 16) or substrate reduction therapy (n = 2), and ferritin was found to decrease 2016-01-01T00:00:00Z2016 Mar2025-04-04T08:50:52.227Z2019-03-27T03:10:16ZS-EPMC48073892700789510.1590/1678-4685-GMB-2015-0125