{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(3)"],"submitter":["Foster GR"],"pubmed_abstract":["<h4>Background</h4>Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice.<h4>Methods</h4>A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhoti"],"journal":["PloS one"],"pagination":["e0151703"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4809570"],"repository":["biostudies-literature"],"pubmed_title":["Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort."],"pmcid":["PMC4809570"],"pubmed_authors":["Foti G","Picciotto A","Basho J","GUARD-C Study Group","Tundo P","Augustyniak K","Szlauer B","Foster GR","Bocakova J","Banyai T","Lipczynski A","Amedea A","Bevanda M","Varkonyi I","D'angelo S","Correa MC","Vafiadi-Zoubouli I","Cattelan AM","Fabri M","Di Perri G","Saracco GM","Brixko C","Jesic R","Vaczi Z","Coman F","Sharara A","Gomide G","Dimitroulopoulos D","Deron Z","Tsianos E","Faria T","Silva G","Nikolopoulou V","Verhaz A","Hoste P","Bandiera F","Colombo S","Colombo M","Guessab N","Rizzetto M","Pirisi M","Silaghi R","Afredj N","Amoroso P","Parikh S","Martins Junior E","Castellacci R","Memon S","George C","Mansinho K","Nagy I","Erne E","Reddy KR","Brunetto M","Orfanou E","Enyedi J","Pascu O","Tolvaj G","Fernandes JC","Drenaggi D","Gietka A","Mazur W","Ramos JP","Giguere A","Horsmans Y","Matarazzo F","Merat S","Shiffman ML","Teixeira R","Philip M","Pigozzi MG","Arama V","Sporea I","Varghese R","Russo FP","Rao P","Vinelli F","Mulkay JP","Manesis E","Warakomska I","Lengyel G","Nagral A","Alavian SM","Musialik J","Ivanovski L","Nemesanszky E","Akriviades E","Delic D","Nozic D","Joksimovic N","Tornai I","Bastens B","Pereira P","Biglino A","Reynaert H","Mousoulis G","Casinelli K","Peixe P","Baka-Cwierz B","Malhado J","Musat M","Verucchi G","Radowska D","Drakoulis C","Rizzardini G","Lee YN","Trifan A","Mahiou H","Luaia R","Macedo G","Di Giacomo A","Mangia A","Warzee P","Mesihovic R","Lawate P","Hunyady B","Rached AA","Evgenidis N","Laukens P","Hausinger P","Ketikoglou I","Sood A","Holoman J","Nagorni A","Soardo G","Yaghi C","Houmani Z","Decaestecker J","Spinzi G","Zali MR","Curescu M","Ahn SH","Gabr M","Racz I","Ganga R","Krkoska D","Pieri A","Al Ghandoor Z","Berak H","Mello CE","Oltman M","Halota W","Abbas Z","Olszok I","Serejo F","Gheorghe L","Tallarico L","Fried K","Ruiz FJ","Szantova M","Megna AS","Nevens F","Ahmetagic S","Karagiannis I","Makkai E","Esmat G","Costa C","Montalbano M","Guerreiro H","Russello M","Abdou AM","Bourgeois S","Alberto S","Tusnadi A","Janssens F","Szalay F","Livia H","Montalto G","Lasser L","Memoli M","Derbala M","Hanno A","Andreoni M","Vincze A","Al Qameesh J","Hassanein T","Stan M","Piekos T","Sabusco G","Ibrahimpasic N","Elefsiniotis I","Askar H","Lyra A","Acalovschi M","Robaeys G","Giannoulis G","Mimidis K","Ribiczey P","Bellantani S","Sieklucki J","Chiriaco P","Mela M","Shabanaj G","Manolakopoulos S","Ionita-Radu F","Jankovic G","Passariello N","Patai A","Servais B","Mazzeo M","Langlet P","Calkic L","De Galocsy C","Mendes C","Sarmento-Castro R","Stanciu C","Vinci M","Velez J","Orlandini A","Schneider F","Daryani NE","Ferrari C","Gervain J","Szentgyorgyi L","Karatapanis S","Varga M","Lefebvre V","Silva MH","Masood S","Mohsin A","Somani S","Al Gharabally A","Flisiak R","Harxhi A","Monteverde C","Konstantinovic L","Mahindad N","Van Vlierberghe H","Lesch M","Kim Y","Roxo F","Lencu M","Delwaide J","Colletta C","Bakalos G","Bunganic I","Simon K","Coppola C","Preotescu L","Nassiri-Toosi M","Sprengers D","Schreter I","Bellati G","Bassi P","Pietrangelo A","Han SY","Caruntu F","Martinet JP","Van Der Meersch F","Yang J","D'amico E","Assene C","Bhalla A","Rapaccini GL","Motoc A","Attili AF","Jablkowski M","Michielsen P","Santantonio T","Fierbinteanu-Braticevici C","Valente C","Yousry A","Bruno S","Schuller J","Aissaoui M","Zignego AL","Skladany L","Henrion J","Castelli F","Aleixo MJ","Streinu-Cercel A","Raimondo G","Lakner L","Francisci D","Hashmi Z","Paik SW","Kupcova V","Ascione A","Zaarour F","Ozsvar Z","Jarcuska P","Olteanu D","Andreica V","Ferraz ML","Kanatakis S","Demelia L","Quirino T","Pelemis M","Juriens I","Ferenci P","Zuin M","Orszulak G","Craxi A","Debzi N","Miftode E","Ancuta I","Todorovic Z","Omar A","Svorcan P","Cijevschi C","Ahlers S","Cool M","Piekarska A","Mazzella G","Dohaibi A"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Safety-Related Dose Reductions or Discontinuations on Sustained Virologic Response in HCV-Infected Patients: Results from the GUARD-C Cohort.","description":"<h4>Background</h4>Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice.<h4>Methods</h4>A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhoti","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-05-04T16:36:05.308Z","creation":"2019-03-26T22:57:40Z"},"accession":"S-EPMC4809570","cross_references":{"pubmed":["27018988"],"doi":["10.1371/journal.pone.0151703"]}}