{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(4)"],"submitter":["Zaidan M"],"pubmed_abstract":["Noninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were identified in the retrospective French CryoVas survey. MCGN was related to primary Sjögren's syndrome in 22.5% of patients and to lymphoproliferative disorders in 28.7% of patients, and was defined as essential in 48.8% of patients. At presentation, hematuria, proteinuria ≥1 g/d, hypertension, and renal failure were observed in 97.4%, 84.8%, 85.3%, and 82.3% of cases, respectively. Mean±eGFR was 39.5±20.4 ml/min per 1.73 m(2) Membranoproliferative GN was the predominant histologic pattern, observed in 89.6% of cases. Renal interstitium inflammatory infiltrates were observed in 50% of cases. First-line treatment consisted of ste"],"journal":["Journal of the American Society of Nephrology : JASN"],"pagination":["1213-24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4814186"],"repository":["biostudies-literature"],"pubmed_title":["Spectrum and Prognosis of Noninfectious Renal Mixed Cryoglobulinemic GN."],"pmcid":["PMC4814186"],"pubmed_authors":["Brocheriou I","Machet MC","Noel LH","Aaron L","Durieu I","Noel D","Woehl JM","Truchetet F","Hinschberger O","Liozon E","Benarous L","Larroche C","Quemeneur T","Bridoux F","Pozdzik A","Hot A","Vanhille P","Lok C","Frouget T","Abad S","Frances C","Salles-Thomasson E","Onno C","Callard P","Jourde N","Karras A","Pouget-Abadie JF","Soria P","Costedoat-Chalumeau N","Kahn JE","Maillard H","Cougoul P","Huart A","Pajot C","Gutnecht J","Blanchard-Delaunay C","Jouanneau C","Sebille G","Gil H","Modesto-Segonds A","Legallicier B","Saadoun D","Lazaro E","Bonnet F","Duong Van Huyen JP","Geffray L","Leger JM","Combe C","Combe B","Cribier B","Hermine O","Pagnoux C","Senet P","Croue A","Loustaud-Ratti V","de Saint-Martin L","Zenone T","Guillaudeau A","Cordonnier C","Rullier P","Leblond V","Kaplanski G","Kemmeny JL","Belenotti P","Cacoub P","Cathebras P","Fraisse T","Rivalan J","Chiche L","Rouvier P","Daniel L","Defuentes G","Perceau G","Francois A","Francois H","Matignon M","Somogyi A","Augusto JF","Goujon JM","Thiercelin-Legrand MF","Nochy D","Woehl-Kremer B","Makdassi R","Piette AM","Lacraz A","Vivet B","Hummel A","Ronco P","Michel C","Sarrot-Reynauld F","Meyer O","Lepreux S","Launay D","Le Guenno G","Weiller PJ","Onuifarasoaniaina S","Ly K","Limal N","Marie I","CryoVas study group","Queyrel V","Ferlicot S","Vagneur JP","Serratrice J","Evon P","Hachulla E","Terrier B","Schaeverbeke T","Nove-Josserand R","Mariette X","Diot E","Plaisier E","Chosidow O","Seror R","Dijoud F","Lambotte O","Martin A","Carrat F","Bakir R","Blaison G","Rioux-Leclercq N","Modiano P","Verpont MC","Perlat A","Doucet L","Zaidan M","Desvaux D","Felix S","Beneton N"],"additional_accession":[]},"is_claimable":false,"name":"Spectrum and Prognosis of Noninfectious Renal Mixed Cryoglobulinemic GN.","description":"Noninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were identified in the retrospective French CryoVas survey. MCGN was related to primary Sjögren's syndrome in 22.5% of patients and to lymphoproliferative disorders in 28.7% of patients, and was defined as essential in 48.8% of patients. At presentation, hematuria, proteinuria ≥1 g/d, hypertension, and renal failure were observed in 97.4%, 84.8%, 85.3%, and 82.3% of cases, respectively. Mean±eGFR was 39.5±20.4 ml/min per 1.73 m(2) Membranoproliferative GN was the predominant histologic pattern, observed in 89.6% of cases. Renal interstitium inflammatory infiltrates were observed in 50% of cases. First-line treatment consisted of ste","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-21T18:39:55.583Z","creation":"2019-03-27T03:10:40Z"},"accession":"S-EPMC4814186","cross_references":{"pubmed":["26260165"],"doi":["10.1681/asn.2015020114","10.1681/ASN.2015020114"]}}