biostudies-literatureUnknown27(4)Zaidan MNoninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were identified in the retrospective French CryoVas survey. MCGN was related to primary Sjögren's syndrome in 22.5% of patients and to lymphoproliferative disorders in 28.7% of patients, and was defined as essential in 48.8% of patients. At presentation, hematuria, proteinuria ≥1 g/d, hypertension, and renal failure were observed in 97.4%, 84.8%, 85.3%, and 82.3% of cases, respectively. Mean±eGFR was 39.5±20.4 ml/min per 1.73 m(2) Membranoproliferative GN was the predominant histologic pattern, observed in 89.6% of cases. Renal interstitium inflammatory infiltrates were observed in 50% of cases. First-line treatment consisted of steJournal of the American Society of Nephrology : JASN1213-24https://www.ebi.ac.uk/biostudies/studies/S-EPMC4814186biostudies-literatureSpectrum and Prognosis of Noninfectious Renal Mixed Cryoglobulinemic GN.PMC4814186Brocheriou IMachet MCNoel LHAaron LDurieu INoel DWoehl JMTruchetet FHinschberger OLiozon EBenarous LLarroche CQuemeneur TBridoux FPozdzik AHot AVanhille PLok CFrouget TAbad SFrances CSalles-Thomasson EOnno CCallard PJourde NKarras APouget-Abadie JFSoria PCostedoat-Chalumeau NKahn JEMaillard HCougoul PHuart APajot CGutnecht JBlanchard-Delaunay CJouanneau CSebille GGil HModesto-Segonds ALegallicier BSaadoun DLazaro EBonnet FDuong Van Huyen JPGeffray LLeger JMCombe CCombe BCribier BHermine OPagnoux CSenet PCroue ALoustaud-Ratti Vde Saint-Martin LZenone TGuillaudeau ACordonnier CRullier PLeblond VKaplanski GKemmeny JLBelenotti PCacoub PCathebras PFraisse TRivalan JChiche LRouvier PDaniel LDefuentes GPerceau GFrancois AFrancois HMatignon MSomogyi AAugusto JFGoujon JMThiercelin-Legrand MFNochy DWoehl-Kremer BMakdassi RPiette AMLacraz AVivet BHummel ARonco PMichel CSarrot-Reynauld FMeyer OLepreux SLaunay DLe Guenno GWeiller PJOnuifarasoaniaina SLy KLimal NMarie ICryoVas study groupQueyrel VFerlicot SVagneur JPSerratrice JEvon PHachulla ETerrier BSchaeverbeke TNove-Josserand RMariette XDiot EPlaisier EChosidow OSeror RDijoud FLambotte OMartin ACarrat FBakir RBlaison GRioux-Leclercq NModiano PVerpont MCPerlat ADoucet LZaidan MDesvaux DFelix SBeneton NfalseSpectrum and Prognosis of Noninfectious Renal Mixed Cryoglobulinemic GN.Noninfectious mixed cryoglobulinemic GN (MCGN) has been poorly investigated. We analyzed presentation and outcome of 80 patients with biopsy-proven MCGN, which were identified in the retrospective French CryoVas survey. MCGN was related to primary Sjögren's syndrome in 22.5% of patients and to lymphoproliferative disorders in 28.7% of patients, and was defined as essential in 48.8% of patients. At presentation, hematuria, proteinuria ≥1 g/d, hypertension, and renal failure were observed in 97.4%, 84.8%, 85.3%, and 82.3% of cases, respectively. Mean±eGFR was 39.5±20.4 ml/min per 1.73 m(2) Membranoproliferative GN was the predominant histologic pattern, observed in 89.6% of cases. Renal interstitium inflammatory infiltrates were observed in 50% of cases. First-line treatment consisted of ste2016-01-01T00:00:00Z2016 Apr2025-04-21T18:39:55.583Z2019-03-27T03:10:40ZS-EPMC48141862626016510.1681/asn.201502011410.1681/ASN.2015020114