{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Huang Y"],"pubmed_abstract":["MicroRNAs (miRNAs) have important roles in post-transcriptional regulation of gene expression. During viral infection, viruses utilize hosts to enhance their replication by altering cellular miRNAs. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays crucial roles in the antiviral responses. In this study, two miRNAs (miR-9041 and miR-9850) from Macrobrachium rosenbergii were found to promote white spot syndrome virus (WSSV) replication. The up-regulation of miR-9041 or miR-9850 suppresses STAT expression in the gills of M. rosenbergii, which subsequently down-regulates the expression of its downstream dynamin (Dnm) genes: Dnm1, Dnm2, and Dnm3. Knockdown of miR-9041 and miR-9850 restricts WSSV replication by up-regulating STAT and Dnm gene expressio"],"journal":["Scientific reports"],"pagination":["23643"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4814834"],"repository":["biostudies-literature"],"pubmed_title":["Two host microRNAs influence WSSV replication via STAT gene regulation."],"pmcid":["PMC4814834"],"pubmed_authors":["Huang Y","Wang W","Ren Q"],"additional_accession":[]},"is_claimable":false,"name":"Two host microRNAs influence WSSV replication via STAT gene regulation.","description":"MicroRNAs (miRNAs) have important roles in post-transcriptional regulation of gene expression. During viral infection, viruses utilize hosts to enhance their replication by altering cellular miRNAs. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway plays crucial roles in the antiviral responses. In this study, two miRNAs (miR-9041 and miR-9850) from Macrobrachium rosenbergii were found to promote white spot syndrome virus (WSSV) replication. The up-regulation of miR-9041 or miR-9850 suppresses STAT expression in the gills of M. rosenbergii, which subsequently down-regulates the expression of its downstream dynamin (Dnm) genes: Dnm1, Dnm2, and Dnm3. Knockdown of miR-9041 and miR-9850 restricts WSSV replication by up-regulating STAT and Dnm gene expressio","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-04-25T17:36:56.769Z","creation":"2019-03-27T03:10:44Z"},"accession":"S-EPMC4814834","cross_references":{"pubmed":["27029712"],"doi":["10.1038/srep23643"]}}