{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muthuri SG"],"funding":["GlaxoSmithKline","Pfizer","Crucell (Johnson &amp; Johnson)","Canadian Institutes of Health Research/SickKids Foundation","Sanofi-Pasteur","Merck","Canadian Institutes of Health Research Catalyst","Public Health Agency of Canada","Instituto de Salud Carlos III","University of Toronto Dean&apos;s Fund Pilot Study","F. Hoffmann-La Roche","Canadian Pediatric Society","Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["192-204"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4814862"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(3)"],"pubmed_abstract":["<h4>Background</h4>The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.<h4>Methods</h4>A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) 'pandemic influenza'. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids.<h4>Results</h4>Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64-1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44-1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71-1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55-0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54-0·85; P = 0·001)].<h4>Conclusions</h4>Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support."],"journal":["Influenza and other respiratory viruses"],"pubmed_title":["Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis."],"pmcid":["PMC4814862"],"funding_grant_id":["MR/J011266/1","CL-2007-21-012","CAT86860","XG08-049R","11/46/12"],"pubmed_authors":["Nguyen-Van-Tam JS","Islam QT","Hu X","Li XL","Leonardi-Bee J","Barhoush MM","Bingisser R","Bettinger J","Myles PR","Schweiger B","Poliquin PG","Kudo K","Venkatesan S","Stephan F","Higuera Iglesias AL","PRIDE Consortium Investigators","Viasus D","Vidmar T","Lim WS","Seale AC","Gerardin P","Fanella S","Bassetti M","Al Khuwaitir TS","El Rhaffouli H","Hu J","Echavarria M","Hoffmann M","Langenegger E","Mickiene A","Linko R","Somer A","Pecavar B","Yu Q","Kyaw WM","Denholm JT","Cao B","Giannella M","Baez C","Anovadiya AP","Jimenez MF","Skret-Magierlo J","Marcone DN","Dominguez SR","Sertogullarindan B","Souza TM","Bouza E","Kuzman I","Torres A","Ozbay B","Tran D","Vaudry W","McGeer A","Cui W","Siqueira MM","Cilloniz C","Kandeel A","Knight M","Bantar C","Khandaker G","Al Masri M","Honarvar B","de Lourdes Aguiar-Oliveira M","Booy R","Polack FP","Zarogoulidis P","Bozkurt I","Amin R","Zuo W","Velyvyte D","Paul M","Torun SH","Tabarsi P","Keijzers G","Leibovici L","Herberg J","Chan KK","Kusznierz G","Chinbayar T","Fraser J","Ozkan M","Chen Y","van Zwol A","Escobar H","Mohn KG","Parekh D","Bertisch B","Li H","Azziz-Baumgartner E","Florek-Michalska A","Rath BA","Loh TP","Rahman M","Manabe T","Marczynska M","Du B","Lankarani KB","Gormley S","Borja-Aburto VH","Dashti-Khavidaki S","Sarrouf EB","Gotberg S","Gao Z","Beovic B","Macbeth D","Libster R","Rascon-Pacheco A","Dubnov-Raz G","Refaey S","Rodriguez AH","Kemen C","Lahlou Amine I","Mastalir FP","Cuezzo MR","Liu P","Carratala J","Kojic M","Bonmarin I","Moradi A","Cox RJ","Burgmann H","Muthuri SG","Gubbels S","Gerrard J","Poeppl W","Bao J","Smith FG","Oliva ME","Talarek E","Memish ZA","Tripathi C","Celjuska-Tosev E","Hoeger PH","Maltezos E","Tang JW","Bautista E","Moghadami M","Mikic D","Khalili H","Madanat F","Zhang W","Duarte PA","Basher A","Leo YS","Al Mamun A","Ballester-Orcal E","Metan G","Uyeki TM","Koay ES","Moriconi L","Mayo-Montero E","Kwan AM","Nymadawa P","Araujo WN"],"additional_accession":[]},"is_claimable":false,"name":"Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09-related pneumonia: an individual participant data meta-analysis.","description":"<h4>Background</h4>The impact of neuraminidase inhibitors (NAIs) on influenza-related pneumonia (IRP) is not established. Our objective was to investigate the association between NAI treatment and IRP incidence and outcomes in patients hospitalised with A(H1N1)pdm09 virus infection.<h4>Methods</h4>A worldwide meta-analysis of individual participant data from 20 634 hospitalised patients with laboratory-confirmed A(H1N1)pdm09 (n = 20 021) or clinically diagnosed (n = 613) 'pandemic influenza'. The primary outcome was radiologically confirmed IRP. Odds ratios (OR) were estimated using generalised linear mixed modelling, adjusting for NAI treatment propensity, antibiotics and corticosteroids.<h4>Results</h4>Of 20 634 included participants, 5978 (29·0%) had IRP; conversely, 3349 (16·2%) had confirmed the absence of radiographic pneumonia (the comparator). Early NAI treatment (within 2 days of symptom onset) versus no NAI was not significantly associated with IRP [adj. OR 0·83 (95% CI 0·64-1·06; P = 0·136)]. Among the 5978 patients with IRP, early NAI treatment versus none did not impact on mortality [adj. OR = 0·72 (0·44-1·17; P = 0·180)] or likelihood of requiring ventilatory support [adj. OR = 1·17 (0·71-1·92; P = 0·537)], but early treatment versus later significantly reduced mortality [adj. OR = 0·70 (0·55-0·88; P = 0·003)] and likelihood of requiring ventilatory support [adj. OR = 0·68 (0·54-0·85; P = 0·001)].<h4>Conclusions</h4>Early NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-25T17:37:31.853Z","creation":"2019-03-27T03:10:44Z"},"accession":"S-EPMC4814862","cross_references":{"pubmed":["26602067"],"doi":["10.1111/irv.12363"]}}