{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["113(10)"],"submitter":["Miyamae M"],"pubmed_abstract":["<h4>Background</h4>This study aims to explore novel microRNAs in plasma for screening cancer and predicting clinical outcomes in pancreatic cancer (PCa) patients using a microRNA array-based approach.<h4>Methods</h4>We used the Toray 3D-Gene microRNA array-based approach to compare plasma levels between PCa patients and healthy volunteers.<h4>Results</h4>(1) Six oncogenic microRNAs (miR-615-5p, -744, -575, -557, -675, and -550a) with high expression in plasma were selected. (2) By quantitative RT-PCR using plasma samples from 94 PCa patients and 68 healthy volunteers, a significantly higher level of plasma miR-744 in PCa patients than in healthy volunteers was validated in small-scale analysis (P=0.0038), two independent cohort analyses, and large-scale analysis (P<0.0001, AUC 0.8307). (3)"],"journal":["British journal of cancer"],"pagination":["1467-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4815891"],"repository":["biostudies-literature"],"pubmed_title":["Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer."],"pmcid":["PMC4815891"],"pubmed_authors":["Ochiai T","Otsuji E","Komatsu S","Shiozaki A","Ikoma H","Okamoto K","Kawaguchi T","Ichikawa D","Miyamae M","Hirajima S","Imamura T","Ohashi T","Konishi H","Taniguchi H","Okajima W","Morimura R"],"additional_accession":[]},"is_claimable":false,"name":"Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer.","description":"<h4>Background</h4>This study aims to explore novel microRNAs in plasma for screening cancer and predicting clinical outcomes in pancreatic cancer (PCa) patients using a microRNA array-based approach.<h4>Methods</h4>We used the Toray 3D-Gene microRNA array-based approach to compare plasma levels between PCa patients and healthy volunteers.<h4>Results</h4>(1) Six oncogenic microRNAs (miR-615-5p, -744, -575, -557, -675, and -550a) with high expression in plasma were selected. (2) By quantitative RT-PCR using plasma samples from 94 PCa patients and 68 healthy volunteers, a significantly higher level of plasma miR-744 in PCa patients than in healthy volunteers was validated in small-scale analysis (P=0.0038), two independent cohort analyses, and large-scale analysis (P<0.0001, AUC 0.8307). (3)","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Nov","modification":"2025-04-04T20:13:20.472Z","creation":"2019-03-27T03:10:49Z"},"accession":"S-EPMC4815891","cross_references":{"pubmed":["26505678"],"doi":["10.1038/bjc.2015.366"]}}