{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6"],"submitter":["Wang L"],"pubmed_abstract":["Members of the Trimeric Autotransporter Adhesin (TAA) family play a crucial role in the adhesion of Gram-negative pathogens to host cells, but the immunopathogenesis of TAAs remains unknown. Our previous studies demonstrated that Adh from Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is required for full bacterial pathogenicity. Alveolar macrophages are the first line of defense against respiratory infections. This study compared the interactions between porcine alveolar macrophages (PAMs) and wild-type A. pleuropneumoniae (5b WT) or an Adh-deletion strain (5b ΔAdh) via gene microarray, immunoprecipitation and other technologies. We found that Adh was shown to interact with the PAMs membrane protein OR5M11, an olfactory receptor, resulting in the high-level secretion of IL-8 by act"],"journal":["Scientific reports"],"pagination":["24058"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4820727"],"repository":["biostudies-literature"],"pubmed_title":["Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release."],"pmcid":["PMC4820727"],"pubmed_authors":["Lei L","Zhang J","Feng X","Zhang H","Sun C","Han W","Qin W","Richard PL","Wang L","Du C","Che Y","Gu J","Bao C"],"additional_accession":[]},"is_claimable":false,"name":"Adh enhances Actinobacillus pleuropneumoniae pathogenicity by binding to OR5M11 and activating p38 which induces apoptosis of PAMs and IL-8 release.","description":"Members of the Trimeric Autotransporter Adhesin (TAA) family play a crucial role in the adhesion of Gram-negative pathogens to host cells, but the immunopathogenesis of TAAs remains unknown. Our previous studies demonstrated that Adh from Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is required for full bacterial pathogenicity. Alveolar macrophages are the first line of defense against respiratory infections. This study compared the interactions between porcine alveolar macrophages (PAMs) and wild-type A. pleuropneumoniae (5b WT) or an Adh-deletion strain (5b ΔAdh) via gene microarray, immunoprecipitation and other technologies. We found that Adh was shown to interact with the PAMs membrane protein OR5M11, an olfactory receptor, resulting in the high-level secretion of IL-8 by act","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-21T16:24:38.45Z","creation":"2019-03-27T03:11:12Z"},"accession":"S-EPMC4820727","cross_references":{"pubmed":["27046446"],"doi":["10.1038/srep24058"]}}