{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Forte TM"],"funding":["NHLBI NIH HHS"],"pagination":["88-93"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4820885"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(2)"],"pubmed_abstract":["Apolipoprotein (apo) A-V is a novel member of the class of exchangeable apo's involved in triacylglycerol (TG) homeostasis. Whereas a portion of hepatic-derived apoA-V is secreted into plasma and functions to facilitate lipoprotein lipase-mediated TG hydrolysis, another portion is recovered intracellularly, in association with cytosolic lipid droplets. Loss of apoA-V function is positively correlated with elevated plasma TG and increased risk of cardiovascular disease. Single nucleotide polymorphisms (SNP) in the <i>APOA5</i> locus can affect transcription efficiency or introduce deleterious amino acid substitutions. Likewise, rare mutations in <i>APOA5</i> that compromise functionality are associated with increased plasma TG and premature myocardial infarction. Genetically engineered mous"],"journal":["Journal of biomedical research"],"pubmed_title":["Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis."],"pmcid":["PMC4820885"],"funding_grant_id":["R37 HL064159"],"pubmed_authors":["Forte TM","Sharma V","Ryan RO"],"additional_accession":[]},"is_claimable":false,"name":"Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.","description":"Apolipoprotein (apo) A-V is a novel member of the class of exchangeable apo's involved in triacylglycerol (TG) homeostasis. Whereas a portion of hepatic-derived apoA-V is secreted into plasma and functions to facilitate lipoprotein lipase-mediated TG hydrolysis, another portion is recovered intracellularly, in association with cytosolic lipid droplets. Loss of apoA-V function is positively correlated with elevated plasma TG and increased risk of cardiovascular disease. Single nucleotide polymorphisms (SNP) in the <i>APOA5</i> locus can affect transcription efficiency or introduce deleterious amino acid substitutions. Likewise, rare mutations in <i>APOA5</i> that compromise functionality are associated with increased plasma TG and premature myocardial infarction. Genetically engineered mous","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Mar","modification":"2025-04-04T12:39:16.388Z","creation":"2019-03-27T03:11:13Z"},"accession":"S-EPMC4820885","cross_references":{"pubmed":["26679785"],"doi":["10.7555/JBR.30.20150059"]}}