biostudies-literatureForte TMNHLBI NIH HHS88-93https://www.ebi.ac.uk/biostudies/studies/S-EPMC4820885biostudies-literatureUnknown30(2)Apolipoprotein (apo) A-V is a novel member of the class of exchangeable apo's involved in triacylglycerol (TG) homeostasis. Whereas a portion of hepatic-derived apoA-V is secreted into plasma and functions to facilitate lipoprotein lipase-mediated TG hydrolysis, another portion is recovered intracellularly, in association with cytosolic lipid droplets. Loss of apoA-V function is positively correlated with elevated plasma TG and increased risk of cardiovascular disease. Single nucleotide polymorphisms (SNP) in the <i>APOA5</i> locus can affect transcription efficiency or introduce deleterious amino acid substitutions. Likewise, rare mutations in <i>APOA5</i> that compromise functionality are associated with increased plasma TG and premature myocardial infarction. Genetically engineered mousJournal of biomedical researchApolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.PMC4820885R37 HL064159Forte TMSharma VRyan ROfalseApolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis.Apolipoprotein (apo) A-V is a novel member of the class of exchangeable apo's involved in triacylglycerol (TG) homeostasis. Whereas a portion of hepatic-derived apoA-V is secreted into plasma and functions to facilitate lipoprotein lipase-mediated TG hydrolysis, another portion is recovered intracellularly, in association with cytosolic lipid droplets. Loss of apoA-V function is positively correlated with elevated plasma TG and increased risk of cardiovascular disease. Single nucleotide polymorphisms (SNP) in the <i>APOA5</i> locus can affect transcription efficiency or introduce deleterious amino acid substitutions. Likewise, rare mutations in <i>APOA5</i> that compromise functionality are associated with increased plasma TG and premature myocardial infarction. Genetically engineered mous2016-01-01T00:00:00Z2016 Mar2025-04-04T12:39:16.388Z2019-03-27T03:11:13ZS-EPMC48208852667978510.7555/JBR.30.20150059