{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Johansen KL"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","CSRD VA"],"pagination":["626-32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4822658"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["<h4>Background and objectives</h4>Frailty is common among patients on dialysis and increases vulnerability to dependency and death.<h4>Design, setting, participants, & measurements</h4>We examined the predictive ability of frailty on the basis of physical performance and self-reported function in participants of a US Renal Data System special study that enrolled a convenience sample of 771 prevalent patients on hemodialysis from 14 facilities in the Atlanta and northern California areas from 2009 to 2011. Performance-based frailty was assessed using direct measures of grip strength (weakness) and gait speed along with weight loss, exhaustion, and low physical activity; poor self-reported function was substituted for weakness and slow gait speed in the self-reported function-based definition. For both definitions, patients meeting three or more criteria were considered frail.<h4>Results</h4>The mean age of 762 patients included in analyses was 57.1±14.2 years old; 240 patients (31%) met the physical performance-based definition of frailty, and 396 (52%) met the self-reported function-based definition. There were 106 deaths during 1.7 (interquartile range, 1.4-2.4) years of follow-up. After adjusting for demographic and clinical characteristics, the hazard ratio (HR) for mortality for the performance-based definition (2.16; 95% confidence interval [95% CI], 1.41 to 3.29) was slightly higher than that of the self-reported function-based definition (HR, 1.93; 95% CI, 1.24 to 3.00). Patients who met the self-report-based definition but not the physical performance definition of frailty (n=192) were not at statistically significantly higher risk of mortality than those who were not frail by either definition (n=330; HR, 1.41; 95% CI, 0.81 to 2.45), but those who met both definitions of frailty (n=204) were at significantly higher risk (HR, 2.46; 95% CI, 1.51 to 4.01).<h4>Conclusions</h4>Frailty, defined using either direct tests of physical performance or self-reported physical function, was associated with higher mortality among patients receiving hemodialysis. Future studies are needed to determine the utility of assessing frailty in clinical practice."],"journal":["Clinical journal of the American Society of Nephrology : CJASN"],"pubmed_title":["Association of Performance-Based and Self-Reported Function-Based Definitions of Frailty with Mortality among Patients Receiving Hemodialysis."],"pmcid":["PMC4822658"],"funding_grant_id":["K24 DK085153","K24DK085446","N01-DK-7-005","UL1 TR000004","K24 DK085446","IK2 CX000527","K23DK093584","K24DK085153","K23 DK093584"],"pubmed_authors":["Dalrymple LS","Grimes B","Johansen KL","Chertow GM","Glidden D","Delgado C","Kaysen GA"],"additional_accession":[]},"is_claimable":false,"name":"Association of Performance-Based and Self-Reported Function-Based Definitions of Frailty with Mortality among Patients Receiving Hemodialysis.","description":"<h4>Background and objectives</h4>Frailty is common among patients on dialysis and increases vulnerability to dependency and death.<h4>Design, setting, participants, & measurements</h4>We examined the predictive ability of frailty on the basis of physical performance and self-reported function in participants of a US Renal Data System special study that enrolled a convenience sample of 771 prevalent patients on hemodialysis from 14 facilities in the Atlanta and northern California areas from 2009 to 2011. Performance-based frailty was assessed using direct measures of grip strength (weakness) and gait speed along with weight loss, exhaustion, and low physical activity; poor self-reported function was substituted for weakness and slow gait speed in the self-reported function-based definition. For both definitions, patients meeting three or more criteria were considered frail.<h4>Results</h4>The mean age of 762 patients included in analyses was 57.1±14.2 years old; 240 patients (31%) met the physical performance-based definition of frailty, and 396 (52%) met the self-reported function-based definition. There were 106 deaths during 1.7 (interquartile range, 1.4-2.4) years of follow-up. After adjusting for demographic and clinical characteristics, the hazard ratio (HR) for mortality for the performance-based definition (2.16; 95% confidence interval [95% CI], 1.41 to 3.29) was slightly higher than that of the self-reported function-based definition (HR, 1.93; 95% CI, 1.24 to 3.00). Patients who met the self-report-based definition but not the physical performance definition of frailty (n=192) were not at statistically significantly higher risk of mortality than those who were not frail by either definition (n=330; HR, 1.41; 95% CI, 0.81 to 2.45), but those who met both definitions of frailty (n=204) were at significantly higher risk (HR, 2.46; 95% CI, 1.51 to 4.01).<h4>Conclusions</h4>Frailty, defined using either direct tests of physical performance or self-reported physical function, was associated with higher mortality among patients receiving hemodialysis. Future studies are needed to determine the utility of assessing frailty in clinical practice.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2021-03-05T08:34:12Z","creation":"2019-03-27T03:11:20Z"},"accession":"S-EPMC4822658","cross_references":{"pubmed":["26792529"],"doi":["10.2215/cjn.03710415","10.2215/CJN.03710415"]}}