{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7"],"submitter":["Hao H"],"pubmed_abstract":["To evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1, 10, and 100 μg/mL) was added into Chemostats. Before and after drug exposure, we monitored (1) population, SCFA products, antimicrobial resistance, and colonization resistance of gut microbiota, and (2) the antimicrobial resistance genes, transferability, virulent genes, pathogenicity of Enterococus faecalis. Results showed that low level of tulathromycin did not exhibit microbiological hazard on resistance selection and colonization resistance. However, high level of tulathromycin (10 and 100 μg/mL) may disturb colonization resistance of human gut microbiota and select antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried resistant gene of ermB, tra"],"journal":["Frontiers in microbiology"],"pagination":["477"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4824762"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Tulathromycin on Colonization Resistance, Antimicrobial Resistance, and Virulence of Human Gut Microbiota in Chemostats."],"pmcid":["PMC4824762"],"pubmed_authors":["Dai M","Liu Z","Zhou S","Hao H","Wang X","Cheng G","Wang Y","Yuan Z"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Tulathromycin on Colonization Resistance, Antimicrobial Resistance, and Virulence of Human Gut Microbiota in Chemostats.","description":"To evaluate microbiological safety of tulathromycin on human intestinal bacteria, tulathromycin (0, 0.1, 1, 10, and 100 μg/mL) was added into Chemostats. Before and after drug exposure, we monitored (1) population, SCFA products, antimicrobial resistance, and colonization resistance of gut microbiota, and (2) the antimicrobial resistance genes, transferability, virulent genes, pathogenicity of Enterococus faecalis. Results showed that low level of tulathromycin did not exhibit microbiological hazard on resistance selection and colonization resistance. However, high level of tulathromycin (10 and 100 μg/mL) may disturb colonization resistance of human gut microbiota and select antimicrobial resistant E. faecalis. Most of the selected resistant E. faecalis carried resistant gene of ermB, tra","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-19T18:05:39.506Z","creation":"2019-03-27T03:11:28Z"},"accession":"S-EPMC4824762","cross_references":{"pubmed":["27092131"],"doi":["10.3389/fmicb.2016.00477"]}}