{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ishiguro K"],"funding":["NICHD NIH HHS"],"pagination":["117-124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4827869"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2(2)"],"pubmed_abstract":["Although epithelial ovarian cancers (EOCs) are initially treated with platinum-based chemotherapy, EOCs vary in platinum responsiveness. Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive EOC cell lines is valuable for development of therapeutic strategies to avoid platinum inefficacy and to exploit platinum sensitivity. TOV-21G devoid of FANCF expression, OV-90 and SKOV-3 were employed as examples of platinum-sensitive, platinum-intermediate and platinum-resistant cell lines, respectively. Antineoplastic agents examined included mitomycin C, doxorubicin, etoposide, gemcitabine, chlorambucil, paclitaxel, triapine and X-rays. Their effectiveness against cell lines was analyzed by clonogenic assays. Cytotoxic profiles of mitomy"],"journal":["Journal of translational science"],"pubmed_title":["Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines."],"pmcid":["PMC4827869"],"funding_grant_id":["K12 HD047018"],"pubmed_authors":["Ishiguro K","Baumann RP","Ratner ES","Sartorelli AC","Rutherford TJ","Penketh PG","Zhu R","Zhu YL","Lin ZP","Shyam K"],"additional_accession":[]},"is_claimable":false,"name":"Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines.","description":"Although epithelial ovarian cancers (EOCs) are initially treated with platinum-based chemotherapy, EOCs vary in platinum responsiveness. Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive EOC cell lines is valuable for development of therapeutic strategies to avoid platinum inefficacy and to exploit platinum sensitivity. TOV-21G devoid of FANCF expression, OV-90 and SKOV-3 were employed as examples of platinum-sensitive, platinum-intermediate and platinum-resistant cell lines, respectively. Antineoplastic agents examined included mitomycin C, doxorubicin, etoposide, gemcitabine, chlorambucil, paclitaxel, triapine and X-rays. Their effectiveness against cell lines was analyzed by clonogenic assays. Cytotoxic profiles of mitomy","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-06-01T12:01:57.689Z","creation":"2019-06-06T15:41:42Z"},"accession":"S-EPMC4827869","cross_references":{"pubmed":["27076919"],"doi":["10.15761/JTS.1000127","10.15761/jts.1000127"]}}