{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maifeld SV"],"funding":["NIAID NIH HHS"],"pagination":["e0153019"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4829208"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Sensitive and precise serology assays are needed to measure the humoral response to antigens of respiratory syncytial virus (RSV) following natural infection or vaccination. We developed and evaluated a collection of electrochemiluminescent (ECL) serology assays using four RSV antigens (F, N, Ga and Gb). To assess the merits of ECL technology, the four ECL serology assays were evaluated using a well-characterized \"gold standard\" panel of acute and convalescent serum samples from fifty-nine RSV-positive and thirty RSV-negative elderly subjects (≥65 years old). The combined results from the four ECL assays demonstrated good concordance to the \"gold standard\" diagnosis, reaching 95% diagnostic sensitivity and 100% diagnostic specificity. Additionally, a combination of ECL assays provided high"],"journal":["PloS one"],"pubmed_title":["Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus."],"pmcid":["PMC4829208"],"funding_grant_id":["R01-AI-45969","R01 AI045969"],"pubmed_authors":["Mok H","Maifeld SV","Yu L","Parhy B","Wang CK","Esser MT","Ulbrandt N","Park S","Zuo F","Carlson M","Yamagata R","Leonardson T","Falsey AR","Ro B","Walsh EE","Chu M","Machhi S","Chio V"],"additional_accession":[]},"is_claimable":false,"name":"Development of Electrochemiluminescent Serology Assays to Measure the Humoral Response to Antigens of Respiratory Syncytial Virus.","description":"Sensitive and precise serology assays are needed to measure the humoral response to antigens of respiratory syncytial virus (RSV) following natural infection or vaccination. We developed and evaluated a collection of electrochemiluminescent (ECL) serology assays using four RSV antigens (F, N, Ga and Gb). To assess the merits of ECL technology, the four ECL serology assays were evaluated using a well-characterized \"gold standard\" panel of acute and convalescent serum samples from fifty-nine RSV-positive and thirty RSV-negative elderly subjects (≥65 years old). The combined results from the four ECL assays demonstrated good concordance to the \"gold standard\" diagnosis, reaching 95% diagnostic sensitivity and 100% diagnostic specificity. Additionally, a combination of ECL assays provided high","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-08T03:42:03.018Z","creation":"2019-03-26T22:57:45Z"},"accession":"S-EPMC4829208","cross_references":{"pubmed":["27070145"],"doi":["10.1371/journal.pone.0153019"]}}