{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Banko AV"],"funding":["Ministry of Education, Science and Technological Development, Republic of Serbia"],"pagination":["e0153498"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4829223"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Epstein-Barr virus (EBV) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially in the undifferentiated carcinoma of nasopharyngeal type (UCNT, World Health Organization type III), which is the dominant histopathological type in high-risk areas. The major EBV oncogene is latent membrane protein 1 (LMP1). LMP1 gene shows variability with different tumorigenic and immunogenic potentials. EBV nuclear antigen 1 (EBNA1) regulates progression of EBV-related tumors; however, the influence of EBNA1 sequence variability on tumor pathogenesis is controversial. The aims of this study were to characterize polymorphisms of EBV genes in non-endemic nasopharyngeal carcinoma biopsies and to investigate potential sequence patterns that correlate with the clinical pres"],"journal":["PloS one"],"pubmed_title":["Characterization of the Variability of Epstein-Barr Virus Genes in Nasopharyngeal Biopsies: Potential Predictors for Carcinoma Progression."],"pmcid":["PMC4829223"],"funding_grant_id":["175073"],"pubmed_authors":["Karalic DZ","Cupic MD","Folic MM","Banko AV","Lazarevic IB","Djukic VB","Cirkovic AM","Jovanovic TP"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of the Variability of Epstein-Barr Virus Genes in Nasopharyngeal Biopsies: Potential Predictors for Carcinoma Progression.","description":"Epstein-Barr virus (EBV) infection is a significant factor in the pathogenesis of nasopharyngeal carcinoma, especially in the undifferentiated carcinoma of nasopharyngeal type (UCNT, World Health Organization type III), which is the dominant histopathological type in high-risk areas. The major EBV oncogene is latent membrane protein 1 (LMP1). LMP1 gene shows variability with different tumorigenic and immunogenic potentials. EBV nuclear antigen 1 (EBNA1) regulates progression of EBV-related tumors; however, the influence of EBNA1 sequence variability on tumor pathogenesis is controversial. The aims of this study were to characterize polymorphisms of EBV genes in non-endemic nasopharyngeal carcinoma biopsies and to investigate potential sequence patterns that correlate with the clinical pres","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-05-29T22:25:36.748Z","creation":"2019-03-26T22:57:45Z"},"accession":"S-EPMC4829223","cross_references":{"pubmed":["27071030"],"doi":["10.1371/journal.pone.0153498"]}}