{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shabalina IG"],"funding":["Forskningsrådet för miljö, areella näringar och samhällsbyggande (FORMAS)","the Swedish Research Council","the European Union Collaborative Project DIABAT","an unrestricted grant from the 3M Company","the Knut and Alice Wallenberg Foundation"],"pagination":["1117-28"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4830884"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(5)"],"pubmed_abstract":["The metabolically inert perfluorinated fatty acids perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) can display fatty acid-like activity in biological systems. The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate. This leads to bioenergetically uncoupled energy dissipation (heat production, thermogenesis). We have examined here the possibility that PFOA/PFOS can directly (re)activate UCP1 in isolated mouse brown-fat mitochondria. In wild-type brown-fat mitochondria, PFOS and PFOA overcame GDP-inhibited thermogenesis, leading to increased oxygen consumption and dissipated membrane potential. The absence of this effect in brown-fat mitochondria from UCP1-ablated mice indicated that it occurred through activ"],"journal":["Archives of toxicology"],"pubmed_title":["Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria."],"pmcid":["PMC4830884"],"funding_grant_id":["621-2013-4661","216-2012-442","278373"],"pubmed_authors":["Shabalina IG","Nedergaard J","Cannon B","Kalinovich AV"],"additional_accession":[]},"is_claimable":false,"name":"Metabolically inert perfluorinated fatty acids directly activate uncoupling protein 1 in brown-fat mitochondria.","description":"The metabolically inert perfluorinated fatty acids perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) can display fatty acid-like activity in biological systems. The uncoupling protein 1 (UCP1) in brown adipose tissue is physiologically (re)activated by fatty acids, including octanoate. This leads to bioenergetically uncoupled energy dissipation (heat production, thermogenesis). We have examined here the possibility that PFOA/PFOS can directly (re)activate UCP1 in isolated mouse brown-fat mitochondria. In wild-type brown-fat mitochondria, PFOS and PFOA overcame GDP-inhibited thermogenesis, leading to increased oxygen consumption and dissipated membrane potential. The absence of this effect in brown-fat mitochondria from UCP1-ablated mice indicated that it occurred through activ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-22T11:59:25.404Z","creation":"2019-03-27T02:11:29Z"},"accession":"S-EPMC4830884","cross_references":{"pubmed":["26041126"],"doi":["10.1007/s00204-015-1535-4"]}}