{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hussain I"],"funding":["NHLBI NIH HHS"],"pagination":["e002729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4831074"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["<h4>Background</h4>Right ventricular (RV) dysfunction (RVD) is a poor prognostic factor in heart failure with preserved ejection fraction (HFpEF). The physiological perturbations associated with RVD or RV function indexed to load (RV-pulmonary arterial [PA] coupling) in HFpEF have not been defined. HFpEF patients with marked impairment in RV-PA coupling may be uniquely sensitive to sildenafil.<h4>Methods and results</h4>In a subset of HFpEF patients enrolled in the Phosphodiesteas-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) trial, physiological variables and therapeutic effect of sildenafil were examined relative to the severity of RVD (tricuspid annular plane systolic excursion [TAPSE]) and according to impairment in RV-PA coupling (TAP"],"journal":["Circulation. Heart failure"],"pubmed_title":["Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial."],"pmcid":["PMC4831074"],"funding_grant_id":["U01 HL084889","U109 HL110337","U01 HL084931","U10 HL110262","U01 HL084861","U01 HL084891","U01 HL084890","U10 HL110338","U10 HL110309","U10 HL110342","U10 HL084904","U10 HL110297","U01 HL084907","U10 HL110302","U10 HL110312","U10 HL110337","U10 HL110336"],"pubmed_authors":["Redfield MM","Gallup DS","Hussain I","Borlaug BA","Mohammed SF","Forfia PR","Lewis GD"],"additional_accession":[]},"is_claimable":false,"name":"Impaired Right Ventricular-Pulmonary Arterial Coupling and Effect of Sildenafil in Heart Failure With Preserved Ejection Fraction: An Ancillary Analysis From the Phosphodiesterase-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) Trial.","description":"<h4>Background</h4>Right ventricular (RV) dysfunction (RVD) is a poor prognostic factor in heart failure with preserved ejection fraction (HFpEF). The physiological perturbations associated with RVD or RV function indexed to load (RV-pulmonary arterial [PA] coupling) in HFpEF have not been defined. HFpEF patients with marked impairment in RV-PA coupling may be uniquely sensitive to sildenafil.<h4>Methods and results</h4>In a subset of HFpEF patients enrolled in the Phosphodiesteas-5 Inhibition to Improve Clinical Status And Exercise Capacity in Diastolic Heart Failure (RELAX) trial, physiological variables and therapeutic effect of sildenafil were examined relative to the severity of RVD (tricuspid annular plane systolic excursion [TAPSE]) and according to impairment in RV-PA coupling (TAP","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-26T01:49:20.776Z","creation":"2019-03-27T02:11:30Z"},"accession":"S-EPMC4831074","cross_references":{"pubmed":["27072860"],"doi":["10.1161/circheartfailure.115.002729","10.1161/CIRCHEARTFAILURE.115.002729"]}}