{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(4)"],"submitter":["Rai H"],"pubmed_abstract":["Several researchers have reported significant association of numerous single nucleotide polymorphisms (SNPs) residing in the interleukin-1 (IL-1) gene cluster with coronary artery disease (CAD). However, their association status amongst North Indian ancestry (NIA) have never been systematically assessed. Despite a published meta-analysis on this subject, their association status worldwide as well as amongst different major ancestral subgroups still remains unclear. We therefore decided to prospectively test the association of 11 IL-1 gene cluster SNPs with CAD, vide a case-control study amongst a cohort of NIA and attempted to validate our results with the help of an updated meta-analysis of all relevant published association studies. Included studies were segregated into ancestral subgrou"],"journal":["PloS one"],"pagination":["e0153480"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4831754"],"repository":["biostudies-literature"],"pubmed_title":["Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis."],"pmcid":["PMC4831754"],"pubmed_authors":["Agrawal S","Rai H","Sharma AK","Sinha N","Kumar S"],"additional_accession":[]},"is_claimable":false,"name":"Interleukin-1 Gene Cluster Polymorphisms and Their Association with Coronary Artery Disease: Separate Evidences from the Largest Case-Control Study amongst North Indians and an Updated Meta-Analysis.","description":"Several researchers have reported significant association of numerous single nucleotide polymorphisms (SNPs) residing in the interleukin-1 (IL-1) gene cluster with coronary artery disease (CAD). However, their association status amongst North Indian ancestry (NIA) have never been systematically assessed. Despite a published meta-analysis on this subject, their association status worldwide as well as amongst different major ancestral subgroups still remains unclear. We therefore decided to prospectively test the association of 11 IL-1 gene cluster SNPs with CAD, vide a case-control study amongst a cohort of NIA and attempted to validate our results with the help of an updated meta-analysis of all relevant published association studies. Included studies were segregated into ancestral subgrou","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2026-04-30T07:10:56.468Z","creation":"2019-03-26T22:57:47Z"},"accession":"S-EPMC4831754","cross_references":{"pubmed":["27078871"],"doi":["10.1371/journal.pone.0153480"]}}