{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alcaide ML"],"funding":["National Institute of Allergy and Infectious Diseases","National Center for Advancing Translational Sciences","NICHD NIH HHS","NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","National Institute of Child Health and Human Development"],"pagination":["e0153045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4831836"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Bacterial vaginosis (BV) is the most common female reproductive tract infection and is associated with an increased risk of acquiring and transmitting HIV by a mechanism that is not well understood. Gamma delta (GD) T cells are essential components of the adaptive and innate immune system, are present in the female reproductive tract, and play an important role in epithelial barrier protection. GD1 cells predominate in the mucosal tissue and are important in maintaining mucosal integrity. GD2 cells predominate in peripheral blood and play a role in humoral immunity and in the immune response to pathogens. HIV infection is associated with changes in GD T cells frequencies in the periphery and in the female reproductive tract. The objective of this study is to evaluate if changes in vaginal "],"journal":["PloS one"],"pubmed_title":["Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study."],"pmcid":["PMC4831836"],"funding_grant_id":["U01-AI-103390","U01-AI-031834","UL1 TR000454","U01-AI-042590","U01 AI034994","U01 AI034993","U01 AI035004","UL1-TR000004","U01-AI-034989","U01 HL146203","U01-AI-103397","UL1TR000460 and 1KL2TR000461","U01 AI103401","KL2 TR000461","U01 AI103408","UL1 TR000460","P30 AI073961","U01 AI034989","U01 AI031834","U01-AI-103401","UL1-TR000454","U01 AI103397","U01 HD032632","UL1 TR000004","U01-AI-034994","1KL2TR000461","U01-AI-034993","UL1TR000460","U01-AI-035004","K23HD074489","U01 AI103390","U01-AI-103408","K23 HD074489","P30AI073961","U01-HD-032632","U01 AI042590"],"pubmed_authors":["Strbo N","Jones DL","Arheart K","Bolivar H","Fischl MA","Rodriguez VJ","Romero L","Martinez O","Podack ER","Alcaide ML"],"additional_accession":[]},"is_claimable":false,"name":"Bacterial Vaginosis Is Associated with Loss of Gamma Delta T Cells in the Female Reproductive Tract in Women in the Miami Women Interagency HIV Study (WIHS): A Cross Sectional Study.","description":"Bacterial vaginosis (BV) is the most common female reproductive tract infection and is associated with an increased risk of acquiring and transmitting HIV by a mechanism that is not well understood. Gamma delta (GD) T cells are essential components of the adaptive and innate immune system, are present in the female reproductive tract, and play an important role in epithelial barrier protection. GD1 cells predominate in the mucosal tissue and are important in maintaining mucosal integrity. GD2 cells predominate in peripheral blood and play a role in humoral immunity and in the immune response to pathogens. HIV infection is associated with changes in GD T cells frequencies in the periphery and in the female reproductive tract. The objective of this study is to evaluate if changes in vaginal ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016","modification":"2025-04-06T10:11:56.269Z","creation":"2019-03-26T22:53:49Z"},"accession":"S-EPMC4831836","cross_references":{"pubmed":["27078021"],"doi":["10.1371/journal.pone.0153045"]}}