{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["D'Mello RJ"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","NIEHS NIH HHS","NIGMS NIH HHS"],"pagination":["744-56"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4833724"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epithelial cells. LRRC31 had basal mRNA expression in colonic and airway mucosal epithelium. Esophageal LRRC31 mRNA and protein increased in active EoE and strongly correlated with esophageal eosinophilia and IL13 and CCL26 (chemokine (C-C motif) ligand 26) mRNA expression. IL-13 treatment increased LRRC31 mRNA and protein in air-liquid interface-differentiated esophageal epithelial cells (EPC2s). At baseline, differentiated LRRC31-overexpressing EPC2s had increased barrier function ("],"journal":["Mucosal immunology"],"pubmed_title":["LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium."],"pmcid":["PMC4833724"],"funding_grant_id":["U19 AI070235","P30 DK078392","R01 DK076893","R01 ES011170","T32 GM063483"],"pubmed_authors":["Azouz NP","Hogan SP","Sherrill JD","Caldwell JM","D'Mello RJ","Wen T","Rothenberg ME"],"additional_accession":[]},"is_claimable":false,"name":"LRRC31 is induced by IL-13 and regulates kallikrein expression and barrier function in the esophageal epithelium.","description":"Eosinophilic esophagitis (EoE) is an allergic inflammatory disease of the esophagus featuring increased esophageal interleukin-13 (IL-13) levels and impaired barrier function. Herein, we investigated leucine-rich repeat-containing protein 31 (LRRC31) in human EoE esophageal tissue and IL-13-treated esophageal epithelial cells. LRRC31 had basal mRNA expression in colonic and airway mucosal epithelium. Esophageal LRRC31 mRNA and protein increased in active EoE and strongly correlated with esophageal eosinophilia and IL13 and CCL26 (chemokine (C-C motif) ligand 26) mRNA expression. IL-13 treatment increased LRRC31 mRNA and protein in air-liquid interface-differentiated esophageal epithelial cells (EPC2s). At baseline, differentiated LRRC31-overexpressing EPC2s had increased barrier function (","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-25T17:35:17.671Z","creation":"2019-03-27T02:11:41Z"},"accession":"S-EPMC4833724","cross_references":{"pubmed":["26462420"],"doi":["10.1038/mi.2015.98"]}}