{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Misra M"],"funding":["Science and Technology Center Emergent Behavior of Integrated Cellular Systems","National Institute of General Medical Sciences","NIGMS NIH HHS","National Science Foundation"],"pagination":["1670-1678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4833838"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["110(7)"],"pubmed_abstract":["Regulated deformations of epithelial sheets are frequently foreshadowed by patterning of their mechanical properties. The connection between patterns of cell properties and the emerging tissue deformations is studied in multiple experimental systems, but the general principles remain poorly understood. For instance, it is in general unclear what determines the direction in which the patterned sheet is going to bend and whether the resulting shape transformation will be discontinuous or smooth. Here these questions are explored computationally, using vertex models of epithelial shells assembled from prismlike cells. In response to rings and patches of apical cell contractility, model epithelia smoothly deform into invaginated or evaginated shapes similar to those observed in embryos and tis"],"journal":["Biophysical journal"],"pubmed_title":["Shape Transformations of Epithelial Shells."],"pmcid":["PMC4833838"],"funding_grant_id":["CBET-0939511","1R01GM107103","R01 GM107103"],"pubmed_authors":["Shvartsman SY","Misra M","Audoly B","Kevrekidis IG"],"additional_accession":[]},"is_claimable":false,"name":"Shape Transformations of Epithelial Shells.","description":"Regulated deformations of epithelial sheets are frequently foreshadowed by patterning of their mechanical properties. The connection between patterns of cell properties and the emerging tissue deformations is studied in multiple experimental systems, but the general principles remain poorly understood. For instance, it is in general unclear what determines the direction in which the patterned sheet is going to bend and whether the resulting shape transformation will be discontinuous or smooth. Here these questions are explored computationally, using vertex models of epithelial shells assembled from prismlike cells. In response to rings and patches of apical cell contractility, model epithelia smoothly deform into invaginated or evaginated shapes similar to those observed in embryos and tis","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2026-05-05T09:25:37.196Z","creation":"2019-03-27T02:11:41Z"},"accession":"S-EPMC4833838","cross_references":{"pubmed":["27074691"],"doi":["10.1016/j.bpj.2016.03.009"]}}