{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(5)"],"submitter":["Alakuijala A"],"pubmed_abstract":["<h4>Study objectives</h4>We aimed to analyze nocturnal sleep characteristics of patients with narcolepsy type 1 (narcolepsy with cataplexy) measured by actigraphy in respect to cerebrospinal fluid hypocretin-1 levels of the same patients.<h4>Methods</h4>Actigraphy recording of 1-2 w and hypocretin-1 concentration analysis were done to thirty-six unmedicated patients, aged 7 to 63 y, 50% female. Twenty-six of them had hypocretin-1 levels under 30 pg/mL and the rest had levels of 31-79 pg/mL.<h4>Results</h4>According to actigraphy, patients with very low hypocretin levels had statistically significantly longer sleep latency (P = 0.033) and more fragmented sleep, indicated by both the number of immobile phases of 1 min (P = 0.020) and movement + fragmentation index (P = 0.049). There were no statistically significant differences in the actual sleep time or circadian rhythm parameters measured by actigraphy.<h4>Conclusions</h4>Actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1. Very low hypocretin levels associate with more wake intruding into sleep."],"journal":["Sleep"],"pagination":["1047-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4835302"],"repository":["biostudies-literature"],"pubmed_title":["Hypocretin-1 Levels Associate with Fragmented Sleep in Patients with Narcolepsy Type 1."],"pmcid":["PMC4835302"],"pubmed_authors":["Alakuijala A","Sarkanen T","Partinen M"],"additional_accession":[]},"is_claimable":false,"name":"Hypocretin-1 Levels Associate with Fragmented Sleep in Patients with Narcolepsy Type 1.","description":"<h4>Study objectives</h4>We aimed to analyze nocturnal sleep characteristics of patients with narcolepsy type 1 (narcolepsy with cataplexy) measured by actigraphy in respect to cerebrospinal fluid hypocretin-1 levels of the same patients.<h4>Methods</h4>Actigraphy recording of 1-2 w and hypocretin-1 concentration analysis were done to thirty-six unmedicated patients, aged 7 to 63 y, 50% female. Twenty-six of them had hypocretin-1 levels under 30 pg/mL and the rest had levels of 31-79 pg/mL.<h4>Results</h4>According to actigraphy, patients with very low hypocretin levels had statistically significantly longer sleep latency (P = 0.033) and more fragmented sleep, indicated by both the number of immobile phases of 1 min (P = 0.020) and movement + fragmentation index (P = 0.049). There were no statistically significant differences in the actual sleep time or circadian rhythm parameters measured by actigraphy.<h4>Conclusions</h4>Actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1. Very low hypocretin levels associate with more wake intruding into sleep.","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 May","modification":"2025-04-19T01:23:50.929Z","creation":"2019-03-27T02:11:49Z"},"accession":"S-EPMC4835302","cross_references":{"pubmed":["26856902"],"doi":["10.5665/sleep.5750"]}}