biostudies-literatureUnknown39(5)Alakuijala A<h4>Study objectives</h4>We aimed to analyze nocturnal sleep characteristics of patients with narcolepsy type 1 (narcolepsy with cataplexy) measured by actigraphy in respect to cerebrospinal fluid hypocretin-1 levels of the same patients.<h4>Methods</h4>Actigraphy recording of 1-2 w and hypocretin-1 concentration analysis were done to thirty-six unmedicated patients, aged 7 to 63 y, 50% female. Twenty-six of them had hypocretin-1 levels under 30 pg/mL and the rest had levels of 31-79 pg/mL.<h4>Results</h4>According to actigraphy, patients with very low hypocretin levels had statistically significantly longer sleep latency (P = 0.033) and more fragmented sleep, indicated by both the number of immobile phases of 1 min (P = 0.020) and movement + fragmentation index (P = 0.049). There were no statistically significant differences in the actual sleep time or circadian rhythm parameters measured by actigraphy.<h4>Conclusions</h4>Actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1. Very low hypocretin levels associate with more wake intruding into sleep.Sleep1047-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC4835302biostudies-literatureHypocretin-1 Levels Associate with Fragmented Sleep in Patients with Narcolepsy Type 1.PMC4835302Alakuijala ASarkanen TPartinen MfalseHypocretin-1 Levels Associate with Fragmented Sleep in Patients with Narcolepsy Type 1.<h4>Study objectives</h4>We aimed to analyze nocturnal sleep characteristics of patients with narcolepsy type 1 (narcolepsy with cataplexy) measured by actigraphy in respect to cerebrospinal fluid hypocretin-1 levels of the same patients.<h4>Methods</h4>Actigraphy recording of 1-2 w and hypocretin-1 concentration analysis were done to thirty-six unmedicated patients, aged 7 to 63 y, 50% female. Twenty-six of them had hypocretin-1 levels under 30 pg/mL and the rest had levels of 31-79 pg/mL.<h4>Results</h4>According to actigraphy, patients with very low hypocretin levels had statistically significantly longer sleep latency (P = 0.033) and more fragmented sleep, indicated by both the number of immobile phases of 1 min (P = 0.020) and movement + fragmentation index (P = 0.049). There were no statistically significant differences in the actual sleep time or circadian rhythm parameters measured by actigraphy.<h4>Conclusions</h4>Actigraphy gives additional information about the stabilization of sleep in patients with narcolepsy type 1. Very low hypocretin levels associate with more wake intruding into sleep.2016-01-01T00:00:00Z2016 May2025-04-19T01:23:50.929Z2019-03-27T02:11:49ZS-EPMC48353022685690210.5665/sleep.5750