{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang W"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","National Institute of Health","National Natural Science Foundation of China","American Diabetes Association"],"pagination":["7-11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4836606"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["595"],"pubmed_abstract":["The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin significantly increased the locomotion. Relative to control animals treated with IgG Fc peptide, rats receiving irisin demonstrated a marked increase in total travel distance, ambulatory counts and time, and vertical counts and time. These changes were associated with a significant decrease in resting time. Central treatment of irisin also induced significant increases in oxygen consumption, carbon dioxide production and heat production, indicating an increase in metabolic ac"],"journal":["Neuroscience letters"],"pubmed_title":["Irisin: A myokine with locomotor activity."],"pmcid":["PMC4836606"],"funding_grant_id":["5R37DK043225","R01 HL105114","81,390,354","#1-13-BS-225","HL105114","81,330,010","R37 DK043225","R01 HL122664"],"pubmed_authors":["Zhang W","Chang L","Li Z","Li J","Chai B","Zhang C","Zhang R","Chen E","Mulholland M"],"additional_accession":[]},"is_claimable":false,"name":"Irisin: A myokine with locomotor activity.","description":"The mechanisms underlying alterations in brain functions in response to physical exercise are not fully understood. The present study examined the central effect of irisin, a 112 amino acid polypeptide hormone secreted from the skeletal muscle after exercise, on the locomotion in rats. Central administration of irisin significantly increased the locomotion. Relative to control animals treated with IgG Fc peptide, rats receiving irisin demonstrated a marked increase in total travel distance, ambulatory counts and time, and vertical counts and time. These changes were associated with a significant decrease in resting time. Central treatment of irisin also induced significant increases in oxygen consumption, carbon dioxide production and heat production, indicating an increase in metabolic ac","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 May","modification":"2025-04-18T13:38:55.361Z","creation":"2019-03-27T02:11:56Z"},"accession":"S-EPMC4836606","cross_references":{"pubmed":["25841790"],"doi":["10.1016/j.neulet.2015.03.069"]}}