{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Felix AS"],"funding":["Intramural NIH HHS","NCI NIH HHS"],"pagination":["djv158"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4836803"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["107(9)"],"pubmed_abstract":["Background
Stage is a critical determinant of treatment among endometrial carcinoma patients; understanding patterns of tumor spread may suggest approaches to improve staging. Specifically, the importance of exfoliation of endometrial carcinoma cells through the fallopian tubes into the peritoneum is ill defined. We assessed the hypothesis that tubal ligation (TL), which should impede transtubal passage of cells, is associated with lower endometrial carcinoma stage at presentation and, consequently, lower mortality.Methods
The NRG Oncology/Gynecologic Oncology Group (GOG) 210 Trial included 4489 endometrial carcinoma patients who completed a risk factor questionnaire that included TL history. Pathology data were derived from clinical reports and central review. We used logi"],"journal":["Journal of the National Cancer Institute"],"pubmed_title":["Relationships of Tubal Ligation to Endometrial Carcinoma Stage and Mortality in the NRG Oncology/ Gynecologic Oncology Group 210 Trial."],"pmcid":["PMC4836803"],"funding_grant_id":["UG1 CA189867","CA27469","CA 37517","U10 CA180850","U10 CA027469","U10 CA180868","U10 CA037517","U10 CA180822","1 U10 CA180822","UG1 CA233230"],"pubmed_authors":["Downs LS","Walker JL","Sherman ME","McMeekin DS","Brinton LA","Felix AS","Zaino R","Cohn DE","Moore RG","Creasman WT","Mutch D","Soslow RA"],"additional_accession":[]},"is_claimable":false,"name":"Relationships of Tubal Ligation to Endometrial Carcinoma Stage and Mortality in the NRG Oncology/ Gynecologic Oncology Group 210 Trial.","description":"Background
Stage is a critical determinant of treatment among endometrial carcinoma patients; understanding patterns of tumor spread may suggest approaches to improve staging. Specifically, the importance of exfoliation of endometrial carcinoma cells through the fallopian tubes into the peritoneum is ill defined. We assessed the hypothesis that tubal ligation (TL), which should impede transtubal passage of cells, is associated with lower endometrial carcinoma stage at presentation and, consequently, lower mortality.Methods
The NRG Oncology/Gynecologic Oncology Group (GOG) 210 Trial included 4489 endometrial carcinoma patients who completed a risk factor questionnaire that included TL history. Pathology data were derived from clinical reports and central review. We used logi","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Sep","modification":"2026-05-29T18:27:00.61Z","creation":"2019-03-27T02:11:56Z"},"accession":"S-EPMC4836803","cross_references":{"pubmed":["26089540"],"doi":["10.1093/jnci/djv158"]}}