biostudies-literatureUnknown107(9)Georgy SR<h4>Background</h4>The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN and the PI3K/AKT/mTOR signaling pathway. GRHL3 is highly expressed in all tissues derived from the surface ectoderm, including the oral cavity, raising a question about its potential role in suppression of head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>We explored the tumor suppressor role of Grhl3 in HNSCC using a conditional knockout (Grhl3 (∆/-) /K14Cre (+) ) mouse line (n = 26) exposed to an oral chemical carcinogen. We defined the proto-oncogenic pathway activated in the HNSCC derived from these mice and assessed it in primary human HNSCC samples, normal oral epithelial cell lines carryingJournal of the National Cancer Institutedjv152https://www.ebi.ac.uk/biostudies/studies/S-EPMC4836819biostudies-literatureIdentification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.PMC4836819Srivastava SJane SMMcLean CAAuden ADworkin SCangkrama MDarido CGeorgy SRPartridge DfalseIdentification of a Novel Proto-oncogenic Network in Head and Neck Squamous Cell Carcinoma.<h4>Background</h4>The developmental transcription factor Grainyhead-like 3 (GRHL3) plays a critical tumor suppressor role in the mammalian epidermis through direct regulation of PTEN and the PI3K/AKT/mTOR signaling pathway. GRHL3 is highly expressed in all tissues derived from the surface ectoderm, including the oral cavity, raising a question about its potential role in suppression of head and neck squamous cell carcinoma (HNSCC).<h4>Methods</h4>We explored the tumor suppressor role of Grhl3 in HNSCC using a conditional knockout (Grhl3 (∆/-) /K14Cre (+) ) mouse line (n = 26) exposed to an oral chemical carcinogen. We defined the proto-oncogenic pathway activated in the HNSCC derived from these mice and assessed it in primary human HNSCC samples, normal oral epithelial cell lines carrying2015-01-01T00:00:00Z2015 Sep2026-05-05T16:47:05.399Z2019-03-27T02:11:56ZS-EPMC48368192606379110.1093/jnci/djv152