{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xiong C"],"funding":["NIA NIH HHS","NIDDK NIH HHS"],"pagination":["1499-506"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4836885"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["86(16)"],"pubmed_abstract":["<h4>Objective</h4>To determine whether and how longitudinal rates of change in MRI volumetrics, CSF concentrations of Alzheimer-related proteins, molecular imaging of cerebral fibrillar amyloid with PET using the [(11)C] benzothiazole tracer, Pittsburgh compound B (PiB), and cognition were associated among asymptomatic middle-aged to older individuals.<h4>Methods</h4>Multivariate mixed models for repeated measures were used to assess the correlations on the rates of changes across markers.<h4>Results</h4>Among 209 asymptomatic middle-aged to older individuals longitudinally followed for up to 11 years (mean 6.7 years), a faster intraindividual decrease in CSF Aβ42 was associated with a faster increase in PiB mean cortical standardized uptake value ratio (MCSUVR, p = 0.04), but not others. "],"journal":["Neurology"],"pubmed_title":["Longitudinal relationships among biomarkers for Alzheimer disease in the Adult Children Study."],"pmcid":["PMC4836885"],"funding_grant_id":["R01 AG034119","P01 AG026276","P50 AG005681","P01 AG003991","K23 DK094982"],"pubmed_authors":["Jasielec MS","Sutphen CL","Hassenstab J","Weng H","Fagan AM","Xiong C","Benzinger TL","Buckles V","Grant E","Moulder KL","Head D","Morris JC"],"additional_accession":[]},"is_claimable":false,"name":"Longitudinal relationships among biomarkers for Alzheimer disease in the Adult Children Study.","description":"<h4>Objective</h4>To determine whether and how longitudinal rates of change in MRI volumetrics, CSF concentrations of Alzheimer-related proteins, molecular imaging of cerebral fibrillar amyloid with PET using the [(11)C] benzothiazole tracer, Pittsburgh compound B (PiB), and cognition were associated among asymptomatic middle-aged to older individuals.<h4>Methods</h4>Multivariate mixed models for repeated measures were used to assess the correlations on the rates of changes across markers.<h4>Results</h4>Among 209 asymptomatic middle-aged to older individuals longitudinally followed for up to 11 years (mean 6.7 years), a faster intraindividual decrease in CSF Aβ42 was associated with a faster increase in PiB mean cortical standardized uptake value ratio (MCSUVR, p = 0.04), but not others. ","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-04T11:41:03.494Z","creation":"2019-03-27T02:11:56Z"},"accession":"S-EPMC4836885","cross_references":{"pubmed":["27009258"],"doi":["10.1212/WNL.0000000000002593","10.1212/wnl.0000000000002593"]}}