{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(16)"],"submitter":["Gao DD"],"pubmed_abstract":["<h4>Aim</h4>To investigate the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-IL-6, HIL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HIL-6) compared to that of recombinant adenovirus containing either HIL-6 or HGF (Ad-HIL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF).<h4>Methods</h4>The recombinant adenoviruses containing HIL-6 and/or HGF were constructed. We established an ACLF model, and rats were randomly assigned to control, model, Ad-GFP, Ad-HIL-6, Ad-HGF or Ad-HGF-HIL-6 group. We collected serum and liver tissue samples to test pathological changes, biochemical indexes and molecular biological indexes.<h4>Results</h4>Attenuated alanine aminotransferase, prothrombin time, high-mobility group box 1 (HMGB1), endotoxin, tumour necro"],"journal":["World journal of gastroenterology"],"pagination":["4136-48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4837431"],"repository":["biostudies-literature"],"pubmed_title":["Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats."],"pmcid":["PMC4837431"],"pubmed_authors":["Huang WX","Jia B","Fu J","Gao DD","Yang C","Qin B"],"additional_accession":[]},"is_claimable":false,"name":"Recombinant adenovirus containing hyper-interleukin-6 and hepatocyte growth factor ameliorates acute-on-chronic liver failure in rats.","description":"<h4>Aim</h4>To investigate the protective efficacy of recombinant adenovirus containing hyper-interleukin-6 (Hyper-IL-6, HIL-6) and hepatocyte growth factor (HGF) (Ad-HGF-HIL-6) compared to that of recombinant adenovirus containing either HIL-6 or HGF (Ad-HIL-6 or Ad-HGF) in rats with acute-on-chronic liver failure (ACLF).<h4>Methods</h4>The recombinant adenoviruses containing HIL-6 and/or HGF were constructed. We established an ACLF model, and rats were randomly assigned to control, model, Ad-GFP, Ad-HIL-6, Ad-HGF or Ad-HGF-HIL-6 group. We collected serum and liver tissue samples to test pathological changes, biochemical indexes and molecular biological indexes.<h4>Results</h4>Attenuated alanine aminotransferase, prothrombin time, high-mobility group box 1 (HMGB1), endotoxin, tumour necro","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-22T10:09:03.139Z","creation":"2019-06-06T15:43:32Z"},"accession":"S-EPMC4837431","cross_references":{"pubmed":["27122664"],"doi":["10.3748/wjg.v22.i16.4136"]}}