{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Blas-Rus N"],"funding":["European Research Council"],"pagination":["11389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4838898"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7"],"pubmed_abstract":["Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation. Here we have identified an unexpected role for Aurora A kinase in antigen-driven T-cell activation. We find that Aurora A is phosphorylated at the immunological synapse (IS) during TCR-driven cell contact. Inhibition of Aurora A with pharmacological agents or genetic deletion in human or mouse T cells severely disrupts the dynamics of microtubules and CD3ζ-bearing vesicles at the IS. The absence of Aurora A activity also impairs the activation of early signalling molecules downstream of the TCR and the expression of IL-2, CD25 and CD69. Aurora A inhibition causes delocalized clustering of Lck at the IS and decreases phosphorylation levels of tyrosine kinase Lck, thus ind"],"journal":["Nature communications"],"pubmed_title":["Aurora A drives early signalling and vesicle dynamics during T-cell activation."],"pmcid":["PMC4838898"],"funding_grant_id":["334763","294340"],"pubmed_authors":["Sanchez-Madrid F","de Carcer G","Alarcon B","Malumbres M","Borroto A","Jorge I","Vazquez J","Bustos-Moran E","Blas-Rus N","Camafeita E","Perez de Castro I","Martin-Cofreces NB"],"additional_accession":[]},"is_claimable":false,"name":"Aurora A drives early signalling and vesicle dynamics during T-cell activation.","description":"Aurora A is a serine/threonine kinase that contributes to the progression of mitosis by inducing microtubule nucleation. Here we have identified an unexpected role for Aurora A kinase in antigen-driven T-cell activation. We find that Aurora A is phosphorylated at the immunological synapse (IS) during TCR-driven cell contact. Inhibition of Aurora A with pharmacological agents or genetic deletion in human or mouse T cells severely disrupts the dynamics of microtubules and CD3ζ-bearing vesicles at the IS. The absence of Aurora A activity also impairs the activation of early signalling molecules downstream of the TCR and the expression of IL-2, CD25 and CD69. Aurora A inhibition causes delocalized clustering of Lck at the IS and decreases phosphorylation levels of tyrosine kinase Lck, thus ind","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-22T20:02:51.386Z","creation":"2019-03-27T02:12:05Z"},"accession":"S-EPMC4838898","cross_references":{"pubmed":["27091106"],"doi":["10.1038/ncomms11389"]}}