biostudies-literatureUnknown11(4)Dhana K<h4>Background</h4>Whether being metabolically healthy obese (MHO)-defined by the presence of obesity in the absence of metabolic syndrome-is associated with subsequent cardiovascular disease (CVD) remains unclear and may depend on the participants' age. We examined the association of being MHO with CVD risk in the elderly.<h4>Methods and findings</h4>This study included 5,314 individuals (mean age 68 years) from the prospective population-based Rotterdam Study. We categorized our population in groups according to body mass index (BMI) and presence and absence of metabolic syndrome, and estimated the hazard ratio (HR) and 95% confidence interval (95%CI) for every group by using Cox proportional hazard models. Among 1048 (19.7%) obese individuals we identified 260 (24.8%) MHO subjects. OverPloS onee0154273https://www.ebi.ac.uk/biostudies/studies/S-EPMC4839559biostudies-literatureMetabolically Healthy Obesity and the Risk of Cardiovascular Disease in the Elderly Population.PMC4839559Dhana KKoolhaas CMKavousi MFranco OHHofman AIkram MAvan Rossum EFfalseMetabolically Healthy Obesity and the Risk of Cardiovascular Disease in the Elderly Population.<h4>Background</h4>Whether being metabolically healthy obese (MHO)-defined by the presence of obesity in the absence of metabolic syndrome-is associated with subsequent cardiovascular disease (CVD) remains unclear and may depend on the participants' age. We examined the association of being MHO with CVD risk in the elderly.<h4>Methods and findings</h4>This study included 5,314 individuals (mean age 68 years) from the prospective population-based Rotterdam Study. We categorized our population in groups according to body mass index (BMI) and presence and absence of metabolic syndrome, and estimated the hazard ratio (HR) and 95% confidence interval (95%CI) for every group by using Cox proportional hazard models. Among 1048 (19.7%) obese individuals we identified 260 (24.8%) MHO subjects. Over2016-01-01T00:00:00Z20162025-04-19T11:24:58.035Z2019-03-26T22:53:50ZS-EPMC48395592710077910.1371/journal.pone.0154273