{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hamilton PW"],"funding":["NEI NIH HHS"],"pagination":["206-215"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4842149"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145"],"pubmed_abstract":["The frog, Xenopus laevis, possesses a high capacity to regenerate various larval tissues, including the lens, which is capable of complete regeneration from the cornea epithelium. However, the molecular signaling mechanisms of cornea-lens regeneration are not fully understood. Previous work has implicated the involvement of the Wnt signaling pathway, but molecular studies have been very limited. Iris-derived lens regeneration in the newt (Wolffian lens regeneration) has shown a necessity for active Wnt signaling in order to regenerate a new lens. Here we provide evidence that the Wnt signaling pathway plays a different role in the context of cornea-lens regeneration in Xenopus. We examined the expression of frizzled receptors and wnt ligands in the frog cornea epithelium. Numerous frizzled"],"journal":["Experimental eye research"],"pubmed_title":["Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling."],"pmcid":["PMC4842149"],"funding_grant_id":["R01 EY009844","R01 EY023979"],"pubmed_authors":["Henry JJ","Hamilton PW","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"Lens regeneration from the cornea requires suppression of Wnt/β-catenin signaling.","description":"The frog, Xenopus laevis, possesses a high capacity to regenerate various larval tissues, including the lens, which is capable of complete regeneration from the cornea epithelium. However, the molecular signaling mechanisms of cornea-lens regeneration are not fully understood. Previous work has implicated the involvement of the Wnt signaling pathway, but molecular studies have been very limited. Iris-derived lens regeneration in the newt (Wolffian lens regeneration) has shown a necessity for active Wnt signaling in order to regenerate a new lens. Here we provide evidence that the Wnt signaling pathway plays a different role in the context of cornea-lens regeneration in Xenopus. We examined the expression of frizzled receptors and wnt ligands in the frog cornea epithelium. Numerous frizzled","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Apr","modification":"2025-04-29T10:14:19.747Z","creation":"2019-03-27T02:12:16Z"},"accession":"S-EPMC4842149","cross_references":{"pubmed":["26778749"],"doi":["10.1016/j.exer.2016.01.003"]}}